Bahk Young Yil, Kim Jeonga, Ahn Seong Kyu, Na Byoung-Kuk, Chai Jong-Yil, Kim Tong-Soo
Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju 27478, Korea.
Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, UAB Comprehensive Diabetes Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Korean J Parasitol. 2018 Dec;56(6):545-552. doi: 10.3347/kjp.2018.56.6.545. Epub 2018 Dec 31.
Plasmodium vivax is more challenging to control and eliminate than P. falciparum due to its more asymptomatic infections with low parasite densities making diagnosis more difficult, in addition to its unique biological characteristics. The potential re-introduction of incidence cases, either through borders or via human migrations, is another major hurdle to sustained control and elimination. The Republic of Korea has experienced re-emergence of vivax malaria in 1993 but is one of the 32 malaria-eliminating countries to-date. Despite achieving successful nationwide control and elimination of vivax malaria, the evolutionary characteristics of vivax malaria isolates in the Republic of Korea have not been fully understood. In this review, we present an overview of the genetic variability of such isolates to increase understanding of the epidemiology, diversity, and dynamics of vivax populations in the Republic of Korea.
由于间日疟原虫具有更多无症状感染且寄生虫密度低，使得诊断更加困难，再加上其独特的生物学特性，因此相较于恶性疟原虫，控制和消除间日疟原虫更具挑战性。通过边境或人口迁移导致发病病例的潜在重新引入，是持续控制和消除间日疟原虫的另一个主要障碍。大韩民国在1993年经历了间日疟的再度出现，但它是迄今为止32个消除疟疾的国家之一。尽管在全国范围内成功控制和消除了间日疟，但大韩民国间日疟分离株的进化特征尚未得到充分了解。在本综述中，我们概述了此类分离株的遗传变异性，以增进对大韩民国间日疟种群的流行病学、多样性和动态的了解。
