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金鸡菊通过 TGF-β1/SMADS/AMPK/NF-κB 通路改善高糖诱导的肾纤维化和炎症。

Coreopsis tinctoria Nutt ameliorates high glucose-induced renal fibrosis and inflammation via the TGF-β1/SMADS/AMPK/NF-κB pathways.

机构信息

College of Traditional Chinese Medicine, Xinjiang Medical University, No. 4 Liyushan Park, Urumuqi, 830011, China.

Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 88 Yuquan Road, Nankai District, Tianjing, 300000, China.

出版信息

BMC Complement Altern Med. 2019 Jan 10;19(1):14. doi: 10.1186/s12906-018-2410-7.

DOI:10.1186/s12906-018-2410-7
PMID:30630477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6327481/
Abstract

BACKGROUND

Coreopsis tinctoria Nutt is an ethnomedicine widely used in Xinjiang, China. It is consumed as a herbal tea by local Uyghur people to treat high blood pressure and diarrhea. Our previous study confirmed that the ethyl acetate extract of Coreopsis tinctoria (AC) had a protective effect on diabetic nephropathy (DN) in an in vivo experiment. Here we aim to elucidate the protective mechanism of AC and marein, the main ingredient in Coreopsis tinctoria on renal fibrosis and inflammation in vitro under high glucose (HG) conditions.

METHODS

A HG-induced barrier dysfunction model in rat mesangial cells (HBZY-1) was established. The cells were exposed to AC and marein and/or HG for 24 h. Then, the renal protective effects of AC and marein via transforming growth factor-β1 (TGF-β1)/Smads, AMP-activated kinase protein (AMPK), and nuclear factor kappa beta (NF-κB) signaling were assessed.

RESULTS

Both AC and marein suppressed rat mesangial cell hyperplasia and significantly attenuated the expression of HG-disrupted fibrotic and inflammatory proteins in HBZY-1 cells. It was also confirmed that AC and marein remarkably attenuated HG-induced renal inflammation and fibrosis by regulating the AMPK, TGF-β1/Smads, and NF-κB signaling pathways.

CONCLUSION

These results indicated that AC and marein may delay the progression of DN, at least in part, by suppressing HG-induced renal inflammation and fibrosis. Marein may be one of the bioactive compounds in AC.

摘要

背景

金鸡菊 Nutt 是一种中国新疆的民族医学常用草药。当地维吾尔族人民将其作为草药茶饮用，用于治疗高血压和腹泻。我们之前的研究证实，金鸡菊的乙酸乙酯提取物（AC）在体内实验中对糖尿病肾病（DN）具有保护作用。在这里，我们旨在阐明 AC 和金鸡菊的主要成分马里因在高糖（HG）条件下体外对肾纤维化和炎症的保护机制。

方法

建立了高糖诱导的大鼠肾小球系膜细胞（HBZY-1）屏障功能障碍模型。将细胞暴露于 AC 和马里因以及 HG 中 24 小时。然后，通过转化生长因子-β1（TGF-β1）/Smads、AMP 激活的蛋白激酶（AMPK）和核因子 kappa beta（NF-κB）信号通路评估 AC 和马里因的肾保护作用。

结果

AC 和马里因均抑制大鼠肾小球系膜细胞增生，并显著减弱 HBZY-1 细胞中 HG 破坏的纤维化和炎症蛋白的表达。还证实 AC 和马里因通过调节 AMPK、TGF-β1/Smads 和 NF-κB 信号通路，显著减弱 HG 诱导的肾炎症和纤维化。

结论

这些结果表明，AC 和马里因可能通过抑制 HG 诱导的肾炎症和纤维化来延缓 DN 的进展，至少部分如此。马里因可能是 AC 中的一种生物活性化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c883/6327481/29c001093870/12906_2018_2410_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c883/6327481/9f38e9406411/12906_2018_2410_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c883/6327481/8848e749bb17/12906_2018_2410_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c883/6327481/e17c14b690f9/12906_2018_2410_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c883/6327481/8a0c412dc8fc/12906_2018_2410_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c883/6327481/2e2db18939a8/12906_2018_2410_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c883/6327481/e2bf409c970e/12906_2018_2410_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c883/6327481/9e657148f4f4/12906_2018_2410_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c883/6327481/29c001093870/12906_2018_2410_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c883/6327481/9f38e9406411/12906_2018_2410_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c883/6327481/8848e749bb17/12906_2018_2410_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c883/6327481/e17c14b690f9/12906_2018_2410_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c883/6327481/8a0c412dc8fc/12906_2018_2410_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c883/6327481/2e2db18939a8/12906_2018_2410_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c883/6327481/e2bf409c970e/12906_2018_2410_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c883/6327481/9e657148f4f4/12906_2018_2410_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c883/6327481/29c001093870/12906_2018_2410_Fig8_HTML.jpg

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