State Key Laboratory for Oxo Synthesis and Selective Oxidation, Center for Excellence in Molecular Synthesis, Suzhou Research Institute of LICP , Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences , Lanzhou 730000 , China.
University of Chinese Academy of Sciences , Beijing 100049 , China.
Org Lett. 2019 Feb 1;21(3):618-622. doi: 10.1021/acs.orglett.8b03652. Epub 2019 Jan 11.
A highly efficient strategy for the enantioselective oxidation of methylene C-H of spirocyclic oxindoles and dihydroquinolinones has been established, in which an earth-abundant manganese catalyst and hydrogen peroxide are used. Noteworthy, the manganese catalyst can be applied to the asymmetric hydroxylation of spirocyclic 2,3-dihydroquinolin-4-ones with 94-99% ee.
已建立一种高效的手性选择性氧化螺环吲哚和二氢喹啉酮亚甲基 C-H 的策略，其中使用了丰富的锰催化剂和过氧化氢。值得注意的是，该锰催化剂可用于螺环 2,3-二氢喹啉-4-酮的不对称羟化，对映选择性高达 94-99%ee。
