Salehi Bahare, Fokou Patrick Valere Tsouh, Sharifi-Rad Mehdi, Zucca Paolo, Pezzani Raffaele, Martins Natália, Sharifi-Rad Javad
Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran.
Antimicrobial and Biocontrol Agents Unit, Department of Biochemistry, Faculty of Science, University of Yaounde 1, Ngoa Ekelle, Annex Fac. Sci., Yaounde 812, Cameroon.
Pharmaceuticals (Basel). 2019 Jan 10;12(1):11. doi: 10.3390/ph12010011.
Naringenin is a flavonoid belonging to flavanones subclass. It is widely distributed in several fruits, bergamot, tomatoes and other fruits, being also found in its glycosides form (mainly naringin). Several biological activities have been ascribed to this phytochemical, among them antioxidant, antitumor, antiviral, antibacterial, anti-inflammatory, antiadipogenic and cardioprotective effects. Nonetheless, most of the data reported have been obtained from or studies. Although some clinical studies have also been performed, the main focus is on naringenin bioavailability and cardioprotective action. In addition, these studies were done in compromised patients (i.e., hypercholesterolemic and overweight), with a dosage ranging between 600 and 800 μM/day, whereas the effect on healthy volunteers is still debatable. In fact, naringenin ability to improve endothelial function has been well-established. Indeed, the currently available data are very promising, but further research on pharmacokinetic and pharmacodynamic aspects is encouraged to improve both available production and delivery methods and to achieve feasible naringenin-based clinical formulations.
柚皮素是一种属于黄烷酮亚类的黄酮类化合物。它广泛分布于多种水果、佛手柑、番茄及其他水果中，也以其糖苷形式（主要是柚皮苷）存在。这种植物化学物质具有多种生物活性，其中包括抗氧化、抗肿瘤、抗病毒、抗菌、抗炎、抗脂肪生成和心脏保护作用。然而，所报道的大多数数据均来自体外或体内研究。尽管也进行了一些临床研究，但其主要重点是柚皮素的生物利用度和心脏保护作用。此外，这些研究是在病情复杂的患者（即高胆固醇血症和超重患者）中进行的，剂量范围为每天600至800微摩尔，而其对健康志愿者的影响仍存在争议。事实上，柚皮素改善内皮功能的能力已得到充分证实。的确，目前可得的数据非常有前景，但鼓励在药代动力学和药效学方面开展进一步研究，以改进现有的生产和给药方法，并实现可行的基于柚皮素的临床制剂。
