Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil;
Hospital Vitória, Americas Medical City, Rio de Janeiro, Brazil.
Pediatrics. 2019 Feb;143(2). doi: 10.1542/peds.2018-2428. Epub 2019 Jan 11.
Ranitidine is a histamine-2 blocker commonly prescribed in PICUs for the prophylaxis of gastrointestinal bleeding and stress ulcers. However, it can be associated to central nervous system side effects, such as delirium, in adults. We present the first case of a child presenting delirium possibly caused by anticholinergic toxidrome secondary to the use of ranitidine, resolving after drug discontinuation. With this case report, we reinforce that a wide variety of clinical conditions can trigger delirium and that the best therapeutic approach is to minimize risk factors.
雷尼替丁是一种组胺 2 受体阻滞剂，常用于儿科重症监护病房预防胃肠道出血和应激性溃疡。然而，它可能会导致成年人出现中枢神经系统副作用，如谵妄。我们报告首例儿童使用雷尼替丁后可能因抗胆碱能中毒引起的谵妄病例，停药后恢复。通过本病例报告，我们强调了各种临床情况都可能引发谵妄，并且最好的治疗方法是最小化风险因素。
