Lipids and Atherosclerosis Research Unit, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, 14004, Spain.
CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Cordoba, 14004, Spain.
Mol Nutr Food Res. 2019 Apr;63(7):e1800870. doi: 10.1002/mnfr.201800870. Epub 2019 Feb 13.
Dysbiosis of gut microbiota is involved in metabolic syndrome (MetS) development, which has a different incidence between men (M) and women (W). The differences in gut microbiota in MetS patients are explored according to gender, and whether consuming two healthy diets, Mediterranean (MED) and low-fat (LF), may, over time, differentially shape the gut microbiota dysbiosis according to gender is evaluated.
All the women from the CORDIOPREV study whose feces samples were available and a similar number of men, matched by the main metabolic variables (N = 246, 123 women and 123 men), and categorized according to the presence or not of MetS are included. Gut microbiota is analyzed at baseline and after 3 years of dietary intervention.
Higher abundance of Collinsella, Alistipes, Anaerotruncus, and Phascolarctobacterium genera is observed in MetS-W than in MetS-M, whereas the abundance of Faecalibacterium and Prevotella genera is higher in MetS-M than in MetS-W. Moreover, higher levels of Desulfovibrio, Roseburia, and Holdemania are observed in men than in women after the consumption of the LF diet.
The results suggest the potential involvement of differences in gut microbiota in the unequal incidence of metabolic diseases between genders, and a sex-dependent effect on shaping the gut microbiota according to diet.
肠道微生物失调与代谢综合征（MetS）的发展有关，男性（M）和女性（W）之间的发病率不同。根据性别探索 MetS 患者的肠道微生物群差异，并评估长期食用两种健康饮食（地中海饮食（MED）和低脂肪饮食（LF））是否会根据性别差异不同地塑造肠道微生物失调。
所有 CORDIOPREV 研究中可提供粪便样本的女性，以及按主要代谢变量匹配的数量相似的男性（N=246，123 名女性和 123 名男性），并根据是否存在 MetS 进行分类。在基线和 3 年的饮食干预后分析肠道微生物群。
与 MetS-M 相比，MetS-W 中Collinsella、Alistipes、Anaerotruncus 和 Phascolarctobacterium 属的丰度更高，而 Faecalibacterium 和 Prevotella 属的丰度在 MetS-M 中更高比 MetS-W。此外，在食用 LF 饮食后，男性体内Desulfovibrio、Roseburia 和Holdemania 的水平高于女性。
研究结果表明，肠道微生物群的差异可能参与了不同性别代谢疾病发病率的差异，以及根据饮食对肠道微生物群形成的性别依赖性影响。
