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盐酸麻黄酮（甲基卡西酮）、乙酰麻黄碱和乙酰麻黄酮的晶体结构及其他性质。

Crystal structures and other properties of ephedrone (methcathinone) hydrochloride, -acetylephedrine and -acetylephedrone.

作者信息

Kuś Piotr, Hellwig Hubert, Kusz Joachim, Książek Maria, Rojkiewicz Marcin, Sochanik Aleksander

机构信息

1Department of Chemistry, University of Silesia, 9 Szkolna Street, 40-006 Katowice, Poland.

2Institute of Physics, University of Silesia, 4 Uniwersytecka Street, 40-007 Katowice, Poland.

出版信息

Forensic Toxicol. 2019;37(1):224-230. doi: 10.1007/s11419-018-0436-7. Epub 2018 Aug 18.

DOI:10.1007/s11419-018-0436-7
PMID:30636989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6315050/
Abstract

PURPOSE

Three compounds obtained from ephedrine were identified and characterized by various instrumental analytical methods. Ephedrone (methcathinone) hydrochloride and its fundamental derivatives -acetylephedrine and -acetylephedrone were analyzed as precursors of a cathinone derivative.

METHODS

The obtained samples were analyzed by gas chromatography coupled with mass spectrometry, nuclear magnetic resonance spectroscopy, infrared and Raman spectroscopy, and X-ray crystallography.

RESULTS

The three compounds were confirmed as: -methyl-2-amino-1-phenylpropan-1-one (methcathinone) hydrochloride, -acetyl--methyl-2-amino-1-phenylpropan-1-one (cathinone derivative), and -acetyl--methyl-2-amino-1-phenylpropan-1-ol (acetyl derivative of ephedrine).

CONCLUSIONS

X-ray crystallography is especially useful for identifying the new designer drugs and their different precursor forms.

摘要

目的

通过各种仪器分析方法对从麻黄碱中获得的三种化合物进行鉴定和表征。将盐酸麻黄酮（甲卡西酮）及其基本衍生物——乙酰麻黄碱和乙酰麻黄酮作为卡西酮衍生物的前体进行分析。

方法

通过气相色谱-质谱联用、核磁共振光谱、红外和拉曼光谱以及X射线晶体学对所得样品进行分析。

结果

这三种化合物被确认为：盐酸α-甲基-2-氨基-1-苯基丙-1-酮（甲卡西酮）、α-乙酰基-α-甲基-2-氨基-1-苯基丙-1-酮（卡西酮衍生物）和α-乙酰基-α-甲基-2-氨基-1-苯基丙-1-醇（麻黄碱的乙酰衍生物）。

结论

X射线晶体学对于鉴定新型设计药物及其不同的前体形式特别有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/6315050/406640021806/11419_2018_436_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/6315050/b1baefd63ace/11419_2018_436_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/6315050/587544c67d6b/11419_2018_436_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/6315050/3d995d06a204/11419_2018_436_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/6315050/406640021806/11419_2018_436_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/6315050/b1baefd63ace/11419_2018_436_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/6315050/587544c67d6b/11419_2018_436_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/6315050/3d995d06a204/11419_2018_436_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4408/6315050/406640021806/11419_2018_436_Fig4_HTML.jpg

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