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来自植物致病真菌的Phleichrome的抗菌和抗肿瘤光动力效应

Antimicrobial and Antitumor Photodynamic Effects of Phleichrome from the Phytopathogenic Fungus .

作者信息

So Kum-Kang, Chun Jeesun, Kim Dae-Hyuk

机构信息

Departments of Molecular Biology and Bioactive Material Sciences, Institute for Molecular Biology and Genetics Chonbuk National University, Jeonju, Jeollabuk-do, Korea.

出版信息

Mycobiology. 2018 Dec 21;46(4):448-451. doi: 10.1080/12298093.2018.1551599. eCollection 2018.

DOI:10.1080/12298093.2018.1551599
PMID:30637154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6322376/
Abstract

Fungal perylenequinones have photodynamic activity and are promising photosensitizers for photodynamic therapy (PDT). Here, we investigated the bactericidal and antitumor activities of phleichrome from the fungal perylenequinone family . Photodynamic bactericidal activity of phleichrome was analyzed by agar-well diffusion method under dark and illuminated conditions. The photodynamic antitumor activity of phleichrome was analyzed in MCF-7, HeLa, SW480, and HepG2 human cancer cell lines using cytotoxicity assays. Photodynamic bactericidal activities against Gram-negative and Gram-positive bacteria were species-specific. Antitumor activity against all tumor cell lines increased under the illuminated condition. Depending on the results of the analyses, Phleichrome has potential for further drug development related to its antibacterial and antitumor activities.

摘要

真菌苝醌类化合物具有光动力活性，是光动力疗法（PDT）中很有前景的光敏剂。在此，我们研究了真菌苝醌家族中的弗氏色素的杀菌和抗肿瘤活性。采用琼脂孔扩散法在黑暗和光照条件下分析了弗氏色素的光动力杀菌活性。使用细胞毒性试验在MCF-7、HeLa、SW480和HepG2人癌细胞系中分析了弗氏色素的光动力抗肿瘤活性。对革兰氏阴性菌和革兰氏阳性菌的光动力杀菌活性具有种属特异性。在光照条件下，对所有肿瘤细胞系的抗肿瘤活性均有所增加。根据分析结果，弗氏色素因其抗菌和抗肿瘤活性在进一步的药物开发方面具有潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c19/6322376/643c1bb9e5b7/TMYB_A_1551599_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c19/6322376/643c1bb9e5b7/TMYB_A_1551599_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c19/6322376/643c1bb9e5b7/TMYB_A_1551599_F0001_B.jpg

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引用本文的文献

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Metabolic engineering of Saccharomyces cerevisiae for the biosynthesis of a fungal pigment from the phytopathogenic fungus Cladosporium phlei.酿酒酵母的代谢工程用于从植物病原真菌草生枝孢菌生物合成一种真菌色素。
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2
Fungal perylenequinones.真菌苝醌类化合物。
Mycol Prog. 2022;21(3):38. doi: 10.1007/s11557-022-01790-4. Epub 2022 Apr 4.

本文引用的文献

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Photodynamic Therapy As a Promising Method Used in the Treatment of Oral Diseases.光动力疗法作为一种有前途的口腔疾病治疗方法。
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Improved production of phleichrome from the phytopathogenic fungus Cladosporium phlei using synthetic inducers and photodynamic ROS production by phleichrome.利用合成诱导剂提高植物病原真菌草枝孢中phleichrome的产量以及phleichrome产生光动力活性氧。
J Biosci Bioeng. 2015 Mar;119(3):289-96. doi: 10.1016/j.jbiosc.2014.08.011. Epub 2014 Sep 16.
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Photodynamic therapy.光动力疗法
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