Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People's Republic of China.
Department of Neurology, School of Medicine, Qingdao Municipal Hospital, Qingdao University, Qingdao, People's Republic of China.
Aging Clin Exp Res. 2019 Dec;31(12):1801-1805. doi: 10.1007/s40520-019-01122-9. Epub 2019 Jan 14.
BACKGROUND/AIMS: Recently, we showed that triggering receptor expressed on myeloid cells 1 (TREM1) was involved in the pathogenesis of Alzheimer's disease (AD) since it modulated microglial phagocytic functions and thus affected amyloid-β clearance in the brain. Interestingly, a soluble form of TREM1 (sTREM1) can be detected in the plasma of human. To date, whether sTREM1 concentrations were altered in the plasma under AD context remained unclear.
In this study, we compared the plasma concentrations of sTREM1 between 110 AD patients and 128 age- and gender-matched controls. Meanwhile, the relationship of sTREM1 concentrations with total tau levels in the plasma of AD patients was also assessed.
We revealed that the concentrations of sTREM1 were significantly increased in AD patients. Meanwhile, the sTREM1 concentrations were gradually increased during disease progression. More importantly, we showed that the sTREM1 concentrations were positively correlated with the levels of total tau in the plasma of AD patients (r = 0.61, P < 0.001). The subsequent subgroup analysis indicated that this correlation was more pronounced in patients with severe dementia (Mini-Mental State Exam score < 10, r = 0.81, P < 0.01).
These findings indicate a potential association between sTREM1 and tau pathology, and further confirm an involvement of this immune receptor in AD pathogenesis.
背景/目的：最近，我们发现髓样细胞触发受体 1（TREM1）参与阿尔茨海默病（AD）的发病机制，因为它调节小胶质细胞的吞噬功能，从而影响大脑中淀粉样β的清除。有趣的是，TREM1 的可溶性形式（sTREM1）可以在人血浆中检测到。迄今为止，AD 背景下血浆中 sTREM1 浓度是否改变仍不清楚。
在这项研究中，我们比较了 110 例 AD 患者和 128 名年龄和性别匹配的对照者血浆中 sTREM1 的浓度。同时，还评估了 AD 患者血浆中 sTREM1 浓度与总tau 水平的关系。
我们发现 AD 患者的 sTREM1 浓度显著升高。同时，sTREM1 浓度随着疾病的进展而逐渐升高。更重要的是，我们发现 sTREM1 浓度与 AD 患者血浆中总 tau 水平呈正相关（r=0.61，P<0.001）。随后的亚组分析表明，这种相关性在痴呆程度严重的患者中更为明显（Mini-Mental State 检查评分<10，r=0.81，P<0.01）。
这些发现表明 sTREM1 与 tau 病理学之间存在潜在关联，并进一步证实了该免疫受体在 AD 发病机制中的参与。
