孕妇血铅水平升高与子痫前期的关联：一项在三级医疗中心开展的研究

Association of raised blood lead levels in pregnant women with preeclampsia: A study at tertiary centre.

作者信息

Sharma Shailja, Goyal Manu, Kumar Pvsn Kiran, Ghosh Raghumoy, Sharma Praveen

机构信息

II Year AIIMS, Jodhpur, India.

Department of Biochemistry All India Institute of Medical Sciences, Jodhpur, India.

出版信息

Taiwan J Obstet Gynecol. 2019 Jan;58(1):60-63. doi: 10.1016/j.tjog.2018.11.011.

DOI:10.1016/j.tjog.2018.11.011

PMID:30638482

Abstract

OBJECTIVE

This study aims to find the blood lead levels in pregnant women and its association with pre-eclampsia.

MATERIAL AND METHODS

The study included 44 healthy pregnant females and 23 pre-eclamptic women. Demographic data and common risk factors for lead toxicity were recorded including age, residence, occupation, husband occupation, passive smoking, use of cosmetics, kajal, surma, receiving supplements/vitamins, history of house remodelling, plumbing, source of potable water, paint in house, use of lead-glazed ceramic and pica. Venous blood was collected and lead level was determined by atomic absorption spectrometry.

RESULTS

The mean blood lead level was 2.38 ± 2.43 ug/dL in controls and 3.42 ± 2.18 ug/dL in preeclamptic women which was significantly higher (p = 0.0132). Strong correlation of BLL was observed with blood pressure in pre-eclamptic women. Pre-eclamptic patients were observed to be at increased risk of being lead exposed in terms of occupation and living conditions.

CONCLUSION

Higher blood lead level is associated with increased risk of preeclampsia. Patients should be counselled for lifestyle modification to prevent complications.

摘要

目的

本研究旨在探究孕妇的血铅水平及其与子痫前期的关联。

材料与方法

该研究纳入了44名健康孕妇和23名单纯收缩期高血压孕妇。记录人口统计学数据和铅中毒的常见风险因素，包括年龄、居住地址、职业、丈夫职业、被动吸烟、化妆品使用情况、kajal（一种眼部化妆品）、surma（一种眼部化妆品）、补充剂/维生素的使用情况、房屋改造史、管道情况、饮用水来源、室内油漆、铅釉陶瓷的使用情况以及异食癖。采集静脉血，采用原子吸收光谱法测定血铅水平。