Medical Research Council (MRC)/Uganda Virus Research Institute (UVRI) and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
University of California, San Francisco, United States of America.
PLoS One. 2019 Jan 14;14(1):e0198460. doi: 10.1371/journal.pone.0198460. eCollection 2019.
People living in fishing communities around Lake Victoria may be suitable for enrolment in HIV prevention trials because of high HIV incidence. We assessed the ability to recruit and retain individuals from fishing communities into an HIV vaccine preparedness cohort study in Masaka, Uganda.
HIV high risk, sero-negative adults (18-49 years) were identified from four fishing villages bordering Lake Victoria through door-to-door HIV counselling and testing (HCT). Interested persons were referred for screening, enrolment, and quarterly follow-up visits at a study clinic located approximately 30-40 kilometres away. Repeat HCT, HIV risk assessment, and evaluation and treatment for sexually transmitted infections were provided. Rates of and factors associated with study dropout were assessed using Poisson regression models.
A total of 940 participants were screened between January 2012 and February 2015, of whom 654 were considered for the analysis. Over a two-year follow-up period, 197 (30.1%) participants dropped out of the study over 778.9 person-years, a dropout rate of 25.3 / 100 person-years of observation. Dropout was associated with being female (aRR = 1.56, 95% confidence interval [CI] 1.12-2.18), being 18-24 years (aRR = 1.64; 95% CI 1.03-2.60) or being 25-34 years (aRR = 1.63; 95% CI 1.04-2.55) compared to being 35+ years; having no education (aRR = 2.02; 95% CI: 1.23-3.31); living in the community for less than one year (aRR = 2.22; 95% CI: 1.46-3.38), or 1-5 years (aRR = 1.68; 95% CI: 1.16-2.45), compared to more than five years.
Our results suggest that individuals from fishing communities can be recruited and retained in longitudinal studies; however, intensified participant tracing may be necessary for women, younger volunteers, those who are less educated and new residents.
由于维多利亚湖周围的渔业社区艾滋病毒发病率较高，这些社区的居民可能适合参加艾滋病毒预防试验。我们评估了在乌干达马萨卡招募和保留来自渔业社区的个人参加艾滋病毒疫苗准备队列研究的能力。
通过挨家挨户的艾滋病毒咨询和检测（HCT），从四个毗邻维多利亚湖的渔村确定艾滋病毒高危、血清阴性的成年人（18-49 岁）。有兴趣的人被转介到距离研究诊所约 30-40 公里的地方进行筛查、登记和每季度随访。提供重复的 HCT、艾滋病毒风险评估以及性传播感染的评估和治疗。使用泊松回归模型评估研究辍学率和相关因素。
2012 年 1 月至 2015 年 2 月期间，共对 940 名参与者进行了筛查，其中 654 名参与者符合分析要求。在两年的随访期间，197 名（30.1%）参与者在 778.9 人年的观察期间退出了研究，辍学率为 25.3/100 人年。与女性（ARR=1.56，95%置信区间[CI]1.12-2.18）、18-24 岁（ARR=1.64；95%CI1.03-2.60）或 25-34 岁（ARR=1.63；95%CI1.04-2.55）相比，35 岁以上（ARR=1.63；95%CI1.04-2.55）的参与者更有可能辍学；未受过教育（ARR=2.02；95%CI：1.23-3.31）；居住在社区不到一年（ARR=2.22；95%CI：1.46-3.38）或 1-5 年（ARR=1.68；95%CI：1.16-2.45），而居住超过五年的参与者辍学率较低。
我们的研究结果表明，渔业社区的个人可以被招募并保留在纵向研究中；然而，可能需要加强对女性、年轻志愿者、受教育程度较低和新居民的参与者追踪。
