Laboratory of Genomic Studies, Sao Paulo State University-UNESP, São José do Rio Preto 15054-000, São Paulo, Brazil.
Departamento de Doenças Infecciosas e Parasitárias, FAMERP, São José do Rio Preto 15090-000, São Paulo, Brazil.
Viruses. 2019 Jan 11;11(1):49. doi: 10.3390/v11010049.
Zika virus (ZIKV) has been associated with serious health conditions, and an intense search to discover different ways to prevent and treat ZIKV infection is underway. Berberine and emodin possess several pharmacological properties and have been shown to be particularly effective against the entry and replication of several viruses. We show that emodin and berberine trigger a virucidal effect on ZIKV. When the virus was exposed to 160 µM of berberine, a reduction of 77.6% in the infectivity was observed; when emodin was used (40 µM), this reduction was approximately 83.3%. Dynamic light scattering data showed that both compounds significantly reduce the hydrodynamic radius of virus particle in solution. We report here that berberine and emodin, two natural compounds, have strong virucidal effect in Zika virus.
寨卡病毒（ZIKV）与严重的健康状况有关，目前正在进行一项激烈的研究，以寻找预防和治疗 ZIKV 感染的新方法。小檗碱和大黄素具有多种药理学特性，并且已被证明对几种病毒的进入和复制特别有效。我们发现大黄素和小檗碱对 ZIKV 具有杀病毒作用。当病毒暴露于 160µM 的小檗碱时，其感染性降低了 77.6%；当使用大黄素（40µM）时，这种降低约为 83.3%。动态光散射数据表明，这两种化合物都能显著降低病毒颗粒在溶液中的水动力半径。我们在这里报告，小檗碱和大黄素这两种天然化合物对寨卡病毒具有强烈的杀病毒作用。
