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接受抗惊厥药物治疗患者的免疫球蛋白A代谢、淋巴细胞功能及组织相容性抗原

Metabolism of immunoglobulin A, lymphocyte function, and histocompatibility antigens in patients on anticonvulsants.

作者信息

Shakir R A, Behan P O, Dick H, Lambie D G

出版信息

J Neurol Neurosurg Psychiatry. 1978 Apr;41(4):307-11. doi: 10.1136/jnnp.41.4.307.

DOI:10.1136/jnnp.41.4.307
PMID:306420
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC493022/
Abstract

Low serum IgA levels were found in patients taking phenytoin, together with evidence of depressed T cell function. There was no correlation between the dose or the serum level. A correlation was found, however, with HL-A status, patients with a low IgA showing increased frequency of HL-A2. It is suggested that epileptic patients with HL-A2 status are likely to develop IgA deficiency when given phenytoin.

摘要

服用苯妥英钠的患者血清免疫球蛋白A（IgA）水平较低，同时有T细胞功能受抑制的证据。剂量或血清水平之间无相关性。然而，发现与人类白细胞抗原（HL-A）状态相关，IgA水平低的患者HL-A2的频率增加。有人提出，具有HL-A2状态的癫痫患者服用苯妥英钠时可能会出现IgA缺乏。

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Metabolism of immunoglobulin A, lymphocyte function, and histocompatibility antigens in patients on anticonvulsants.接受抗惊厥药物治疗患者的免疫球蛋白A代谢、淋巴细胞功能及组织相容性抗原
J Neurol Neurosurg Psychiatry. 1978 Apr;41(4):307-11. doi: 10.1136/jnnp.41.4.307.
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引用本文的文献

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Immunological adverse effects of anticonvulsants. What is their clinical relevance?抗惊厥药的免疫不良反应。它们的临床相关性是什么？
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Immunoglobulins in epilepsy.癫痫中的免疫球蛋白
Springer Semin Immunopathol. 1985;8(1-2):5-28. doi: 10.1007/BF00197244.

本文引用的文献

1
Immunological abnormalities and hydantoins.免疫异常与乙内酰脲类药物
Br Med J. 1972 Jun 3;2(5813):561-3. doi: 10.1136/bmj.2.5813.561.
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A gas-chromatographic method for the simultaneous determination of phenobarbitone, primidone and phenytoin in serum using a nitrogen detector.
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Surface immunoglobulins on the thoracic duct lymphocytes of the congenitally athymic (nude) mouse.先天性无胸腺（裸）小鼠胸导管淋巴细胞上的表面免疫球蛋白
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Folic acid deficiency and epilepsy.叶酸缺乏与癫痫
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Serum immunoglobulins in epilepsy.癫痫患者的血清免疫球蛋白
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Immune imbalance in dysgammaglobulinaemia type IV.IV型免疫球蛋白异常血症中的免疫失衡。
Lancet. 1968 Jan 20;1(7534):110-4. doi: 10.1016/s0140-6736(68)92721-9.
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Hypogammaglobulinemia, primary and secondary: immunoglobulin levels (gamma-G, gamma-A, gamma-M) in one hundred and twenty-five patients.
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10
Inhibition of transformation of normal lymphocytes by plasma factor from patients with Hodgkin's disease and cancer.
Lancet. 1971 Dec 4;2(7736):1265. doi: 10.1016/s0140-6736(71)90586-1.