接受抗惊厥药物治疗患者的免疫球蛋白A代谢、淋巴细胞功能及组织相容性抗原
Metabolism of immunoglobulin A, lymphocyte function, and histocompatibility antigens in patients on anticonvulsants.
作者信息
Shakir R A, Behan P O, Dick H, Lambie D G
出版信息
J Neurol Neurosurg Psychiatry. 1978 Apr;41(4):307-11. doi: 10.1136/jnnp.41.4.307.
Abstract
Low serum IgA levels were found in patients taking phenytoin, together with evidence of depressed T cell function. There was no correlation between the dose or the serum level. A correlation was found, however, with HL-A status, patients with a low IgA showing increased frequency of HL-A2. It is suggested that epileptic patients with HL-A2 status are likely to develop IgA deficiency when given phenytoin.
摘要
服用苯妥英钠的患者血清免疫球蛋白A（IgA）水平较低，同时有T细胞功能受抑制的证据。剂量或血清水平之间无相关性。然而，发现与人类白细胞抗原（HL-A）状态相关，IgA水平低的患者HL-A2的频率增加。有人提出，具有HL-A2状态的癫痫患者服用苯妥英钠时可能会出现IgA缺乏。
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本文引用的文献
1
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Br Med J. 1972 Jun 3;2(5813):561-3. doi: 10.1136/bmj.2.5813.561.
2
A gas-chromatographic method for the simultaneous determination of phenobarbitone, primidone and phenytoin in serum using a nitrogen detector.
Clin Chim Acta. 1973 Feb 12;43(3):423-9. doi: 10.1016/0009-8981(73)90482-8.
3
Surface immunoglobulins on the thoracic duct lymphocytes of the congenitally athymic (nude) mouse.先天性无胸腺（裸）小鼠胸导管淋巴细胞上的表面免疫球蛋白
Aust J Exp Biol Med Sci. 1972 Oct;50(5):661-4. doi: 10.1038/icb.1972.58.
4
Folic acid deficiency and epilepsy.叶酸缺乏与癫痫
Drugs. 1974;8(5):366-85. doi: 10.2165/00003495-197408050-00005.
5
Serum immunoglobulins in epilepsy.癫痫患者的血清免疫球蛋白
J Neurol Sci. 1974 Nov;23(3):353-7. doi: 10.1016/0022-510x(74)90153-1.
6
Human immunoglobulin A.
N Engl J Med. 1968 Dec 12;279(24):1327-30. doi: 10.1056/NEJM196812122792408.
7
Abnormalities in IgA-containing mononuclear cells in the gastric lesion of pernicious anaemia.
Lancet. 1968 Oct 19;2(7573):846-9. doi: 10.1016/s0140-6736(68)91001-5.
8
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Lancet. 1968 Jan 20;1(7534):110-4. doi: 10.1016/s0140-6736(68)92721-9.
9
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J Allergy. 1966 Oct;38(4):215-25. doi: 10.1016/0021-8707(66)90055-4.
10
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