1Psychopharmacology and Emotion Research Laboratory (PERL),Department of Psychiatry,University of Oxford,Oxford,UK.
CNS Spectr. 2019 Feb;24(1):54-63. doi: 10.1017/S109285291800130X. Epub 2019 Jan 15.
While impairments in cognitive emotional processing are key to the experience of mood disorders, little is understood of their shared and distinct features across major depressive disorder (MDD) and bipolar disorder (BD). In this review, we discuss the similarities and differences in abnormal emotional processing associated with mood disorders across the cognitive domains of perception, attention, memory, and reward processing, with a particular focus on how these impairments relate to the clinical profile of the disorders. We consider behavioral and neuroimaging evidence, especially that of the growing consensus surrounding mood-congruent biases in cognition, in combination with state- and trait-related characteristics in an attempt to provide a more comprehensive and translational overview of mood disorders. Special consideration is given to the shared phenomenon of mood instability and its role as a potential transdiagnostic marker across the prodrome and maintenance of mood disorders.
虽然认知情绪处理障碍是心境障碍体验的关键，但对于重度抑郁症 (MDD) 和双相情感障碍 (BD) 之间的共同和独特特征，人们知之甚少。在这篇综述中，我们讨论了与心境障碍相关的异常情绪处理在感知、注意、记忆和奖励处理等认知领域中的异同，特别关注这些障碍与疾病临床特征的关系。我们考虑了行为和神经影像学证据，尤其是围绕认知中与情绪一致的偏见的共识，以及与状态和特质相关的特征，试图提供更全面和转化的心境障碍概述。特别考虑了情绪不稳定的共同现象及其作为心境障碍前体和维持阶段的潜在跨诊断标志物的作用。
