Department of Medicine, University of Otago, Christchurch, New Zealand.
Department of Gastroenterology, VU Medical Centre, Amsterdam, the Netherlands.
Nutr Clin Pract. 2019 Aug;34(4):623-630. doi: 10.1002/ncp.10233. Epub 2019 Jan 15.
The low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol (FODMAP) diet is effectively manages irritable bowel syndrome (IBS) symptoms. Long-term low-FODMAP studies rarely report quality of life (QoL). We aimed to determine the effect of low-FODMAP diet on long-term QoL, gastrointestinal (GI) and non-GI symptoms in IBS patients.
A prospective observational study of IBS patients referred for low-FODMAP dietary advice was performed. The primary outcome of QoL and secondary outcomes of GI symptoms, anxiety/depression, fatigue, sleep quality, and happiness were obtained at baseline, 6 weeks (T6), and 6 months (T26).
111 patients were recruited. 91.0%, 71.6%, and 50.5% of participants completed baseline, T6, and T26 assessments, respectively. There were significant improvements in QoL from baseline at T6 and T26 (both P < 0.001). Significant reductions were seen in GI symptoms at T6 and T26 (both P < 0.001), fatigue at T6 and T26 (both P < 0.003), and anxiety at T6 and T26 (both P < 0.007), compared with baseline. A significant reduction was seen for depression (P < 0.010) from baseline at T26, and a significant increase was seen for both happiness and vitality (both P < 0.04) from baseline at T26. There was a significant correlation between GI symptom response and change in QoL, anxiety, depression, and fatigue (all P < 0.034).
Low-FODMAP diet was associated with improved long-term QoL and GI symptoms, reduced fatigue and anxiety/depression, and increased happiness and vitality. These data support a wider range of benefits for IBS patients consuming a low-FODMAP diet.
低可发酵寡糖、双糖、单糖和多元醇（FODMAP）饮食可有效缓解肠易激综合征（IBS）症状。长期低 FODMAP 研究很少报告生活质量（QoL）。我们旨在确定低 FODMAP 饮食对 IBS 患者长期 QoL、胃肠道（GI）和非 GI 症状的影响。
对接受低 FODMAP 饮食建议的 IBS 患者进行前瞻性观察研究。在基线、6 周（T6）和 6 个月（T26）时，获得 QoL 的主要结局和胃肠道症状、焦虑/抑郁、疲劳、睡眠质量和幸福感的次要结局。
共招募 111 名患者。91.0%、71.6%和 50.5%的参与者分别完成了基线、T6 和 T26 评估。与基线相比，T6 和 T26 时 QoL 均显著改善（均 P < 0.001）。T6 和 T26 时胃肠道症状（均 P < 0.001）、疲劳（均 P < 0.003）和焦虑（均 P < 0.007）显著减轻。与基线相比，T26 时抑郁显著降低（P < 0.010），T26 时幸福感和活力显著增加（均 P < 0.04）。胃肠道症状缓解与 QoL、焦虑、抑郁和疲劳的变化呈显著相关（均 P < 0.034）。
低 FODMAP 饮食与改善长期 QoL 和胃肠道症状、减轻疲劳和焦虑/抑郁以及增加幸福感和活力相关。这些数据支持 IBS 患者食用低 FODMAP 饮食具有更广泛的益处。
