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儿童和青少年强迫症的症状维度反应。

Symptom Dimension Response in Children and Adolescents with Obsessive-Compulsive Disorder.

机构信息

a Division of Child and Adolescent Psychiatry , Johns Hopkins University School of Medicine.

b Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry , University of California.

出版信息

J Clin Child Adolesc Psychol. 2019 May-Jun;48(3):529-538. doi: 10.1080/15374416.2018.1540009. Epub 2019 Jan 15.

Abstract

This report examined the nature of obsessive-compulsive disorder (OCD) symptoms nominated for treatment and investigate improvement in OCD symptom dimensions. Youth with OCD ( = 71) participated in a clinical trial that compared exposure-based cognitive behavior therapy (CBT) to psychoeducation plus relaxation training (PRT). Participants completed a baseline assessment to characterize OCD severity. Next, parents and youth collaboratively developed an OCD symptom treatment hierarchy. Afterward, these symptoms were independently reassessed at each session by youth and parents. After 12 sessions, a posttreatment assessment was completed by independent evaluators. A greater incidence of baseline aggressive/checking symptoms predicted a positive CBT treatment response. For parent ratings of youth distress, CBT outperformed PRT across symptom dimensions, but hoarding symptoms exhibited a slower rate of improvement relative to other dimensions across treatments. For youth distress ratings, CBT outperformed PRT across most symptom dimensions. Although symmetry/ordering symptoms exhibited a slower rate of improvement relative to other dimensions across treatments, post hoc tests found no difference in the average distress rating for symmetry/ordering symptoms between treatment groups. Finally, across symptom dimensions, parents reported a linear reduction in youth distress, whereas youth experienced a nonlinear reduction in distress that diminished over treatment. Exposure-based CBT is beneficial for OCD symptoms and remains the principle treatment for pediatric OCD. However, as symmetry/ordering symptoms exhibited improvement from CBT and PRT, there is some shared treatment mechanisms that improves these symptoms. Finally, as youth perceive diminishing distress reduction over time, clinicians are encouraged to employ appropriate reinforcement strategies in treatment.

摘要

本报告探讨了强迫症(OCD)症状的性质,并研究了 OCD 症状维度的改善情况。患有 OCD 的青年(=71)参加了一项临床试验,该试验比较了基于暴露的认知行为疗法(CBT)与心理教育加放松训练(PRT)。参与者完成了基线评估以确定 OCD 严重程度。接下来,父母和青少年共同制定了 OCD 症状治疗层级。之后,青少年和父母会在每次治疗中独立重新评估这些症状。在 12 次治疗后,由独立评估者完成治疗后评估。基线时攻击性/检查症状的发生率更高预示着 CBT 治疗有积极反应。对于父母对青少年痛苦的评估,CBT 在所有症状维度上均优于 PRT,但相对于其他治疗方法,囤积症状的改善速度较慢。对于青少年的痛苦评估,CBT 在大多数症状维度上均优于 PRT。尽管对称/有序症状在治疗过程中相对于其他维度改善速度较慢,但事后检验发现两组之间对称/有序症状的平均痛苦评分没有差异。最后,在所有症状维度上,父母报告青少年痛苦呈线性下降,而青少年的痛苦在治疗过程中逐渐减轻。基于暴露的 CBT 对 OCD 症状有益,仍然是小儿 OCD 的主要治疗方法。但是,由于 CBT 和 PRT 都能改善对称/有序症状,因此存在一些共同的治疗机制可以改善这些症状。最后,随着青少年随着时间的推移感到痛苦减轻,鼓励临床医生在治疗中采用适当的强化策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f43/6754115/91efa2479fba/nihms-1510504-f0001.jpg

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