Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China.
Nanoscale. 2019 Jan 23;11(4):2027-2036. doi: 10.1039/c8nr09064e.
An innovative tungsten-based multifunctional nanoplatform composed of polyethylene glycol (PEG)-modified tungsten nitride nanoparticles (WN NPs) is constructed for tumor treatment. The PEG-WN NPs not only possess strong near-infrared (NIR) absorbance, high photothermal conversion efficiency, and excellent photothermal stability, but also effectively inhibit tumor cells upon 808 nm laser irradiation. After coating with thiolated (2-hydroxypropyl)-β-cyclodextrin (MUA-CD) on the surface, such a nanoplatform can also be used for drug delivery (such as DOX) and presents a synergistic tumor inhibition effect both in vitro and in vivo. Furthermore, the PEG-WN NPs present good contrasting capability for X-ray computed tomography (CT) and photoacoustic (PA) imaging. With PA/CT imaging, the tumor can be accurately positioned for precise treatment. It is worth mentioning that PEG-WN NPs are biodegradable and could be effectively excreted from the body with no appreciable toxicity in vivo. It is expected that this biocompatible multifunctional nanoplatform can serve as a potential candidate for tumor treatment in future clinical applications.
构建了一种由聚乙二醇（PEG）修饰的氮化钨纳米粒子（WN NPs）组成的创新型钨基多功能纳米平台，用于肿瘤治疗。PEG-WN NPs 不仅具有很强的近红外（NIR）吸收能力、高光热转换效率和优异的光热稳定性，而且在 808nm 激光照射下能有效抑制肿瘤细胞。在表面涂覆巯基（2-羟丙基）-β-环糊精（MUA-CD）后，这种纳米平台还可用于药物输送（如 DOX），并在体外和体内均表现出协同的肿瘤抑制作用。此外，PEG-WN NPs 还具有良好的 X 射线计算机断层扫描（CT）和光声（PA）成像对比能力。通过 PA/CT 成像，可以准确地定位肿瘤，进行精确治疗。值得一提的是，PEG-WN NPs 是可生物降解的，在体内无明显毒性，可以被有效排出体外。预计这种生物相容性多功能纳米平台将成为未来临床应用中肿瘤治疗的潜在候选者。
