Interdisciplinary Laboratories for Advanced Materials Physics (i-LAMP) and Dipartimento di Matematica e Fisica, Università Cattolica del Sacro Cuore, Via Musei 41, 25121 Brescia, Italy. luca.gavioli@unicatt and Laboratory of Solid State Physics and Magnetism, Department of Physics and Astronomy, KU Leuven, Celestijnenlaan 200D, 3001 Leuven, Belgium.
Interdisciplinary Laboratories for Advanced Materials Physics (i-LAMP) and Dipartimento di Matematica e Fisica, Università Cattolica del Sacro Cuore, Via Musei 41, 25121 Brescia, Italy. luca.gavioli@unicatt.
Nanoscale. 2019 Jan 23;11(4):1626-1635. doi: 10.1039/c8nr08375d.
Bactericidal nanoparticle coatings are very promising for hindering the indirect transmission of pathogens through cross-contaminated surfaces. The challenge, limiting their employment in nosocomial environments, is the ability of tailoring the coating's physicochemical properties, namely, composition, cytotoxicity, bactericidal spectrum, adhesion to the substrate, and consequent nanoparticles release into the environment. We have engineered a new family of nanoparticle-based bactericidal coatings comprising Ag, Cu, and Mg and synthesized by a green gas-phase technique. These coatings present wide-spectrum bactericidal activity on both Gram-positive and Gram-negative reference strains and tunable physicochemical properties of relevance in view of their "on-field" deployment. The link between material and functional properties is rationalized based on a multidisciplinary and multitechnique approach. Our results pave the way for engineering biofunctional, fully tunable nanoparticle coatings, exploiting an arbitrarily wide number of elements in a straightforward, eco-friendly, high-throughput, one-step process.
杀菌纳米粒子涂层在阻止通过交叉污染表面间接传播病原体方面非常有前景。限制其在医院环境中使用的挑战在于能够调整涂层的物理化学性质，即组成、细胞毒性、杀菌谱、对基底的附着力以及随后纳米粒子释放到环境中。我们通过绿色气相技术合成了一种由 Ag、Cu 和 Mg 组成的新型纳米粒子杀菌涂层。这些涂层对革兰氏阳性和革兰氏阴性参考菌株均具有广谱杀菌活性，并且具有可调节的物理化学性质，这对于它们的“现场”部署非常重要。基于多学科和多技术方法，合理地将材料和功能特性联系起来。我们的研究结果为工程生物功能、完全可调的纳米粒子涂层铺平了道路，可在一个简单、环保、高通量、一步的过程中利用任意数量的元素。
