Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221 005, India.
Department of Histopathology, Lal Path Labs, New Delhi, India.
World J Surg Oncol. 2019 Jan 15;17(1):18. doi: 10.1186/s12957-018-1548-6.
Gastrointestinal tract is the most frequent site of extranodal lymphoma accounting for approximately 40% of all extranodal lymphomas; out of these, non-Hodgkin's lymphoma (NHL) comprises 4% of total cases. Primary lymphoma arising in the colon is very rare comprising only 0.2-1% of all colonic malignancy.
We report two cases of 13- and 20-year-old boys with NHL of colon presenting with abdominal pain and weight loss and discuss the approach to colonic lymphoma after a review of world literature to provide an overview on colonic lymphoma.
Colonic NHL most commonly affects older age group with mean age of diagnosis being 55 years. Abdominal pain and weight loss are the two most common presentations with palpable abdominal mass as physical examination finding in half of the cases.
Colonic lymphoma in young adolescence is rare. Multimodality approach involving both surgery and chemotherapy is the principal mode of treatment. Radiotherapy is used in selected cases. If diagnosed preoperatively, non-surgical management can be attempted.
胃肠道是结外淋巴瘤最常见的部位，约占所有结外淋巴瘤的 40%；其中，非霍奇金淋巴瘤（NHL）占所有病例的 4%。原发于结肠的淋巴瘤非常罕见，仅占所有结肠恶性肿瘤的 0.2-1%。
我们报告了两例 13 岁和 20 岁男孩的结内 NHL，均表现为腹痛和体重减轻，并回顾了世界文献，以提供结内 NHL 的概述，讨论了结肠淋巴瘤的处理方法。
结内 NHL 最常影响老年人群，诊断时的平均年龄为 55 岁。腹痛和体重减轻是最常见的两种表现，一半的病例体格检查可触及腹部肿块。
青少年的结内 NHL 较为罕见。多模式治疗包括手术和化疗是主要的治疗方法。放射治疗仅用于某些特定病例。如果在术前诊断，可以尝试非手术治疗。
