无金属条件下烯烃的分子间碳吡啶化反应：可见光诱导的还原自由基偶联反应

Chen Dan, Xu Lei, Long Tianyu, Zhu Shengqing, Yang Jun, Chu Lingling

Center for Advanced Low-dimension Materials , State Key Laboratory for Modification of Chemical Fibers and Polymer Materials , College of Materials Science and Engineering , Donghua University , Shanghai 201620 , China . Email:

Chem Sci. 2018 Oct 2;9(48):9012-9017. doi: 10.1039/c8sc03493a. eCollection 2018 Dec 28.

An efficient, metal-free strategy for the intermolecular three-component carbopyridylation of styrenes, enabled by Hantzsch ester and visible light, has been described. This versatile protocol gives access to important β-CF pyridines, through the regioselective, sequential formation of two C-C bonds without the use of exogenous catalysts. The value of this benign protocol has been demonstrated through functionalizations of natural-product- and drug-based complex molecules.

已报道了一种高效的、无金属的策略，用于在汉茨希酯和可见光作用下实现苯乙烯的分子间三组分碳吡啶化反应。该通用方法通过区域选择性地依次形成两个碳-碳键，无需使用外源催化剂，即可得到重要的β-CF吡啶。通过对基于天然产物和药物的复杂分子进行官能团化，证明了这种温和方法的价值。