Dorantes-Heredia Rita, Motola-Kuba Daniel, Murphy-Sanchez Carlos, Izquierdo-Tolosa Carlos D, Ruiz-Morales Jose M
Anatomic Pathology Research Department, Fundación Clínica Médica Sur, México City, Mexico.
Medical Oncology Research Department, Fundación Clínica Médica Sur, México City, Mexico.
J Surg Case Rep. 2019 Jan 9;2019(1):rjy358. doi: 10.1093/jscr/rjy358. eCollection 2019 Jan.
Testicular germ cell tumors (TGCTs) are the most frequent type of cancer in young adults. An exceptional event is the spontaneous regression (SR) of the primary tumor. Herein, we describe a burned-out non-seminomatous TGCT case and relevant literature review. A 34-year-old male presenting with low back pain was found to have a retroperitoneal mass upon urotomography. During workup, a heterogeneous testicular mass was evident, and its biopsy showed findings that support the diagnosis of spontaneous tumoral regression. The patient underwent unilateral orchiectomy and a chemotherapy protocol was later initiated, with 85% regression of the retroperitoneal metastatic mass. No progression of the primary tumor has been found. The etiology of SR across different cancer types appears to be associated with the host's immune response and an angiogenic disturbance of the tumor microenvironment. The burned-out phenomenon is a rare event that needs further research into its molecular sequencing.
睾丸生殖细胞肿瘤（TGCTs）是年轻成年人中最常见的癌症类型。原发性肿瘤的自发消退（SR）是一种特殊情况。在此，我们描述一例消退的非精原细胞瘤性TGCT病例并进行相关文献综述。一名34岁男性因腰痛就诊，经尿路造影发现腹膜后肿块。在检查过程中，发现睾丸有一个不均匀肿块，其活检结果支持自发肿瘤消退的诊断。患者接受了单侧睾丸切除术，随后启动了化疗方案，腹膜后转移肿块消退了85%。未发现原发性肿瘤进展。不同癌症类型中SR的病因似乎与宿主的免疫反应以及肿瘤微环境的血管生成紊乱有关。消退现象是一种罕见事件，需要对其分子序列进行进一步研究。
