Center of Health Science, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.
Department of Physical Education, Centro Universitário do Rio Grande do Norte, Brazil.
Phytother Res. 2019 Mar;33(3):856-858. doi: 10.1002/ptr.6258. Epub 2019 Jan 15.
Prolonged use of antiretroviral therapy (ART) has been associated with dyslipidemia and impaired energy substrate oxidation (SOxi). Curcumin is a natural bioactive compound, which interacts with molecular targets and holds important metabolic properties. The aim of this study was to evaluate the effect of curcumin supplementation on energetic metabolism of an adult female with HIV/AIDS and under ART. The intervention was performed with 500 mg/day of curcumin for 27 days. Glycemic and lipid profile and SOxi at rest were evaluated before and after intervention. After intervention, improvement of lipid profile and insulin sensibility was observed. Moreover, there was a positive modulation of SOxi at rest. Oral curcumin supplementation can positively modulate the energy metabolism of people living with HIV/AIDS using the ART. However, clinical studies are required in order to confirm our findings in a representative sample.
长期使用抗逆转录病毒疗法 (ART) 与血脂异常和能量底物氧化 (SOxi) 受损有关。姜黄素是一种天然生物活性化合物，与分子靶标相互作用，具有重要的代谢特性。本研究旨在评估姜黄素补充剂对接受 ART 的 HIV/AIDS 成年女性能量代谢的影响。干预措施为每天 500 毫克姜黄素，共 27 天。在干预前后评估了血糖和血脂谱以及休息时的 SOxi。干预后，观察到血脂谱和胰岛素敏感性改善。此外，休息时的 SOxi 也得到了正向调节。口服姜黄素补充剂可以正向调节接受 ART 的 HIV/AIDS 患者的能量代谢。然而，需要进行临床研究，以便在代表性样本中证实我们的发现。
