Basic and Clinic Sciences Group-Department of Basic Sciences of Health, Pontificia Universidad Javeriana, Cali, Colombia; Nutrition Group, Universidad del Valle, Cali, Colombia.
Division of Child Development and Community Health, University of California, San Diego, La Jolla, CA, USA.
Nutr Metab Cardiovasc Dis. 2019 Mar;29(3):268-278. doi: 10.1016/j.numecd.2018.11.008. Epub 2018 Dec 4.
Increased ferritin levels have been widely associated with cardiovascular risk in adults. Whether ferritin levels and their changes during childhood are related to metabolic syndrome (MetS) at adolescence is unknown. We aimed to evaluate these associations using levels of ferritin at 5, 10 and 16 years and their linear increases and patterns of sustained increased levels across childhood.
There were four samples evaluated according to non-missing values for study variables at each stage (5 years: 562; 10 years: 381; and 16 years: 567 children; non-missing values at any stage: 379). MetS risk was evaluated as a continuous Z score. Patterns of sustained increased ferritin (highest tertile) and slope of the change of ferritin per year across the follow-up were calculated. Ferritin levels in the highest versus lowest tertile at five and 16 years were significantly positively associated with MetS risk Z score at adolescence in boys and these associations were unaffected by adjustment for covariates. Having high, compared to low/moderate ferritin level at 2 or more time periods between 5 and 16 years was related to higher Mets Z-score in boys only [e.g. 5-10 years adjusted-beta (95 %CI):0.26 (0.05-0.48),P < 0.05]. In girls, ferritin Z score at 10 and 16 years was positively and independently associated with HOMA-IR Z score. In girls, the slope of ferritin per year in the highest tertile was positively associated with MetS risk Z-score [adjusted-beta (95 %CI):0.21 (0.05-0.38),P < 0.05].
Ferritin levels throughout childhood are positively related to cardiometabolic risk in adolescence, with associations varying by sex.
铁蛋白水平升高与成年人的心血管风险广泛相关。在儿童期，铁蛋白水平及其变化是否与青春期的代谢综合征（MetS）有关尚不清楚。我们旨在使用 5、10 和 16 岁时的铁蛋白水平以及整个儿童期的线性升高和持续升高水平模式来评估这些关联。
根据每个阶段的研究变量的非缺失值评估了四个样本（5 岁：562；10 岁：381；16 岁：567 名儿童；任何阶段的非缺失值：379）。MetS 风险评估为连续 Z 评分。计算了持续升高的铁蛋白（最高三分位）的模式和整个随访期间铁蛋白每年的变化斜率。男孩在 5 岁和 16 岁时处于最高三分位的铁蛋白水平与青春期时 MetS 风险 Z 评分呈显著正相关，这些关联不受协变量调整的影响。在 5 至 16 岁期间的 2 个或更多时间点具有较高，而非较低/中等铁蛋白水平与男孩仅更高的 Mets Z 评分相关[例如，5-10 岁校正后的β（95%CI）：0.26（0.05-0.48），P<0.05]。在女孩中，10 岁和 16 岁的铁蛋白 Z 评分与 HOMA-IR Z 评分呈正相关且独立相关。在女孩中，最高三分位的铁蛋白每年斜率与 MetS 风险 Z 评分呈正相关[校正后的β（95%CI）：0.21（0.05-0.38），P<0.05]。
整个儿童期的铁蛋白水平与青春期的心血管代谢风险呈正相关，其关联因性别而异。
