轮班工作与亚临床心血管疾病生物标志物：BCOPS 研究。
Shiftwork and Biomarkers of Subclinical Cardiovascular Disease: The BCOPS Study.
机构信息
Department of Epidemiology and Biostatistics, Arnold School of Public Health (Mr Holst, Dr Wirth, Dr Burch); Cancer Prevention and Control Program (Dr Wirth, Dr Burch); College of Nursing (Dr Wirth), University of South Carolina; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia (Ms Mnatsakanova, Dr Charles, Ms Tinney-Zara, Dr Fekedulegn, Dr Andrew, Dr Hartley); WJB Dorn VA Medical Center (Dr Burch), Columbia, South Carolina; Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University of Buffalo, The State University of New York, Buffalo, New York (Dr Violanti).
出版信息
J Occup Environ Med. 2019 May;61(5):391-396. doi: 10.1097/JOM.0000000000001541.
OBJECTIVE
To assess the association of shiftwork with biomarkers of subclinical cardiovascular disease and examine the moderating role of body mass index (BMI) in a police cohort.
METHODS
A cross-sectional analysis was conducted among officers who were categorized as working the day, evening, or night shift. Comparisons with inflammatory biomarkers were performed among shifts using analysis of variance/covariance and further stratified by BMI to assess potential effect modification.
RESULTS
Associations were observed between day and night shiftworkers for leukocytes, tumor necrosis factor alpha, and homocysteine. After BMI stratification, higher c-reactive protein (CRP) levels were observed among evening shiftworkers with a BMI more than or equal to 30 kg/m versus the day shift.
CONCLUSIONS
Future studies examining prospective changes in these markers will allow for more comprehensive evaluation of their association with shiftwork.
目的
评估轮班工作与亚临床心血管疾病生物标志物的关联，并在警察队列中检验体重指数（BMI）的调节作用。
方法
对被归类为上白班、中班或夜班的警察进行横断面分析。使用方差分析/协方差对不同班次进行比较，并根据 BMI 进一步分层，以评估潜在的效应修饰作用。
结果
在白细胞、肿瘤坏死因子-α和同型半胱氨酸方面，观察到上白班和上夜班的轮班工人之间存在关联。在 BMI 分层后，与上白班相比，BMI 大于或等于 30kg/m2 的中班轮班工人的 C 反应蛋白（CRP）水平更高。
结论
未来研究检查这些标志物的前瞻性变化，将允许更全面地评估它们与轮班工作的关联。
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