Lu Yung-Chuan, Wang Chao-Ping, Yu Teng-Hung, Tsai I-Ting, Hung Wei-Chin, Lu I-Cheng, Hsu Chia-Chang, Tang Wei-Hua, Houng Jer-Yiing, Chung Fu-Mei, Yen Jean Mei-Chu
Division of Endocrinologic, E-Da Hospital, I-Shou University, Kaohsiung, 82445 Taiwan.
School of Medicine for International Students, I-Shou University, Kaohsiung, 82445 Taiwan.
Diabetol Metab Syndr. 2017 Oct 16;9:83. doi: 10.1186/s13098-017-0283-4. eCollection 2017.
There is increasing evidence linking a shift work schedule with various adverse health effects. The present study aimed to examine the relationship between shift work and the metabolic syndrome (MetS) in male steel workers, and also the possible mechanism of shift work-related metabolic derangements.
A total of 1732 men aged 42 ± 8 years were enrolled in this cross-sectional study, including 862 day workers and 870 shift workers. Circulating levels of resistin were measured by ELISA using monoclonal specific antibodies.
The shift workers had higher rates of MetS and its components (central obesity, hypertension, and hypertriglyceridemia) than the day workers. In multiple logistic regression analysis, shift work was independently associated with MetS. In further analysis, the shift workers had elevated circulating levels of resistin (13 ± 10 vs. 10 ± 7 ng/mL) and total white blood cell (WBC) count (6.865 ± 1.819 vs. 6.304 ± 1.547 10/L) than the day workers. In addition, both resistin level and total WBC count were significantly associated with shift work, MetS, and its components (body mass index, fasting glucose, triglyceride, and high-density lipoprotein-cholesterol levels), and plasma resistin levels were significantly associated with total WBC count (β = 0.34, p < 0.0001).
Shift work was independently associated with MetS in male steel workers. Resistin and WBC count were associated with shift work-related metabolic derangements.
越来越多的证据表明轮班工作与各种不良健康影响有关。本研究旨在探讨男性钢铁工人轮班工作与代谢综合征（MetS）之间的关系，以及轮班工作相关代谢紊乱的可能机制。
本横断面研究共纳入1732名年龄在42±8岁的男性，其中862名日班工人和870名轮班工人。使用单克隆特异性抗体通过酶联免疫吸附测定法（ELISA）测量抵抗素的循环水平。
轮班工人的MetS及其组成部分（中心性肥胖、高血压和高甘油三酯血症）的发生率高于日班工人。在多因素逻辑回归分析中，轮班工作与MetS独立相关。进一步分析发现，轮班工人的抵抗素循环水平（13±10 vs. 10±7 ng/mL）和白细胞（WBC）总数（6.865±1.819 vs. 6.304±1.547×10⁹/L）高于日班工人。此外，抵抗素水平和白细胞总数均与轮班工作、MetS及其组成部分（体重指数、空腹血糖、甘油三酯和高密度脂蛋白胆固醇水平）显著相关，血浆抵抗素水平与白细胞总数显著相关（β = 0.34，p < 0.0001）。
在男性钢铁工人中，轮班工作与MetS独立相关。抵抗素和白细胞计数与轮班工作相关的代谢紊乱有关。
