Charles Luenda E, Zhao Songzhu, Fekedulegn Desta, Violanti John M, Andrew Michael E, Burchfiel Cecil M
Health Effects Laboratory Division, Biostatistics and Epidemiology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia.
Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo, New York.
Am J Ind Med. 2016 Nov;59(11):1001-1008. doi: 10.1002/ajim.22611. Epub 2016 Jun 1.
Our objective was to assess the influence of shiftwork on change in endothelial function.
This longitudinal study was conducted in 188 police officers (78.2% men). Shiftwork status (day, afternoon, night) was assessed objectively using daily Buffalo, NY payroll work history records. Brachial artery flow-mediated dilation (FMD) was assessed using ultrasound. Mean change in FMD% between 2004-2009 and 2010-2015 was compared across shiftwork using analysis of variance/covariance.
Overall, mean FMD% decreased from 5.74 ± 2.83 to 3.88 ± 2.11 over an average of 7 years among all officers; P < 0.0001. Effect modification by gender was significant. Among men (but not women), those who worked day shifts had a smaller mean (±SE) decrease in FMD% (-0.89 ± 0.35) compared with those who worked the afternoon (-2.69 ± 0.39; P = 0.001) or night shifts (-2.31 ± 0.45; P = 0.020) after risk factor adjustment.
Larger declines in endothelial function were observed among men who worked afternoon or night shifts. Further investigation is warranted. Am. J. Ind. Med. 59:1001-1008, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
我们的目标是评估轮班工作对内皮功能变化的影响。
这项纵向研究纳入了188名警察（78.2%为男性）。使用纽约州布法罗市的每日工资单工作历史记录客观评估轮班工作状态（白班、中班、夜班）。采用超声评估肱动脉血流介导的血管舒张功能（FMD）。使用方差分析/协方差分析比较2004 - 2009年和2010 - 2015年间不同轮班工作的FMD%平均变化。
总体而言，在平均7年的时间里，所有警察的FMD%均值从5.74±2.83降至3.88±2.11；P < 0.0001。性别对结果有显著的效应修正作用。在男性（而非女性）中，经危险因素调整后，与中班（-2.69±0.39；P = 0.001）或夜班（-2.31±0.45；P = 0.020）的警察相比，白班警察的FMD%平均下降幅度较小（-0.89±0.35）。
上中班或夜班的男性内皮功能下降幅度更大。有必要进行进一步调查。《美国工业医学杂志》2016年第59卷：1001 - 1008页。2016年发表。本文为美国政府作品，在美国属于公共领域。
