Department of Psychiatry, Trinity College Dublin, Trinity Centre for Health Sciences, Tallaght University Hospital, Dublin 24, D24 NR0A, Ireland.
Ir J Med Sci. 2019 Aug;188(3):953-958. doi: 10.1007/s11845-019-01967-z. Epub 2019 Jan 16.
The Great Irish Famine (1845-52) saw the Irish population fall by 20% as one million people died and another million emigrated. The Famine occurred at a time when the Irish asylums were growing rapidly anyway, so its precise effects on mental health are difficult although not impossible to study. Three groups merit consideration. First, for adults living through the Famine, starvation and poverty contributed to the continued rise in asylum presentations. Second, babies in utero during the Famine were reported to have accounted for an increase in first admissions when they reached the high-risk age for mental illness (1860-75). Third, the possibility of epigenetic effects (inherited changes in gene expression) as a result of Famine has been discussed as a possible mechanism whereby Famine survivors might have passed on experiences of physical and psychological trauma to their children and subsequent generations in a lasting, biological way. Intriguing as it is, this hypothesis requires further study, as does the distinctly uneven historiography of the Famine in relation to the Irish mental hospitals.
爱尔兰大饥荒(1845-52 年)导致爱尔兰人口减少了 20%,100 万人死亡,100 万人移民。大饥荒发生之际,爱尔兰的收容所正在迅速扩张,因此尽管并非不可能,但要研究其对精神健康的确切影响仍具有一定难度。有三个群体值得考虑。首先,对于经历过大饥荒的成年人来说,饥饿和贫困导致收容所的收容人数持续上升。其次,据报道,大饥荒期间在子宫内的婴儿在到达精神疾病高风险年龄(1860-75 年)时,首次入院人数有所增加。第三,由于饥荒而产生的表观遗传效应(基因表达的遗传变化)可能是一种机制,通过这种机制,饥荒幸存者可能以持久的生物学方式将身体和心理创伤的经历传递给他们的孩子和后代。尽管这一假设很有趣,但还需要进一步研究,因为与爱尔兰精神病院相关的大饥荒历史记载明显不均衡。