Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada.
Department of Community Health Sciences, University of Manitoba, Winnipeg, Canada.
PLoS Pathog. 2019 Jan 17;15(1):e1007429. doi: 10.1371/journal.ppat.1007429. eCollection 2019 Jan.
HIV causes several forms of immune dysfunction that need to be addressed in a functional cure for HIV. Immune exhaustion describes a dysfunctional phenotype caused by chronic cellular activation. Lymphocyte activation gene-3 (LAG3) is one of several negative coreceptors known as immune checkpoints that contribute to this exhaustion phenotype. Antibodies targeting immune checkpoints are now used clinically to restore immunity against cancer and hold promise in restoring immunity during HIV infection. Here, we summarize current knowledge surrounding LAG3 and discuss its relevance during HIV infection and the potential for LAG3-targeting antibodies in a functional HIV cure.
HIV 可引起几种形式的免疫功能障碍，在 HIV 的功能性治愈中需要加以解决。免疫衰竭描述了由慢性细胞激活引起的功能障碍表型。淋巴细胞激活基因-3（LAG3）是几种已知的负协同受体之一，称为免疫检查点，有助于这种衰竭表型。针对免疫检查点的抗体目前已在临床上用于恢复对癌症的免疫力，并有望在 HIV 感染期间恢复免疫力。在这里，我们总结了围绕 LAG3 的现有知识，并讨论了其在 HIV 感染期间的相关性，以及 LAG3 靶向抗体在功能性 HIV 治愈中的潜力。
