School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Brisbane, QLD, Australia; Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, QLD, Australia.
School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Brisbane, QLD, Australia.
Drug Discov Today. 2019 Mar;24(3):858-866. doi: 10.1016/j.drudis.2019.01.004. Epub 2019 Jan 14.
Most microbial infectious diseases can be treated successfully with the remarkable array of antimicrobials current available; however, antimicrobial resistance, adverse effects, and the high cost of antimicrobials are crucial health challenges worldwide. One of the common efforts in addressing this issue lies in improving the existing antibacterial delivery systems. Solid nanoparticles (SNPs) have been widely used as promising strategies to overcome these challenges. In addition, oral delivery is the most common method of drug administration with high levels of patient acceptance. Formulation into NPs can improve drug stability in the harsh gastrointestinal (GI) tract environment, providing opportunities for targeting specific sites in the GI tract, increasing drug solubility and bioavailability, and providing sustained release in the GI tract. Here, we discuss SNPs for the oral delivery of antimicrobials, including solid lipid NPs (SLNs), polymeric NPs (PNs), mesoporous silica NPs (MSNs) and hybrid NPs (HNs). We also discussed about the role of nanotechnology in IV to oral antimicrobial therapy development as well as challenges, clinical transformation, and limitations of SNPs for oral antimicrobial drug delivery.
大多数微生物传染性疾病可以通过目前可用的大量抗菌药物成功治疗；然而，抗菌药物耐药性、不良反应和高成本是全球范围内的重大健康挑战。解决这个问题的常见方法之一在于改进现有的抗菌药物输送系统。固体纳米粒子（SNPs）已被广泛用作克服这些挑战的有前途的策略。此外，口服给药是最常见的药物给药方式，患者接受度高。制成 NPs 可以提高药物在恶劣的胃肠道（GI）环境中的稳定性，为靶向 GI 道中的特定部位提供机会，提高药物溶解度和生物利用度，并在 GI 道中提供持续释放。在这里，我们讨论了 SNPs 用于口服递送抗菌药物，包括固体脂质 NPs（SLNs）、聚合物 NPs（PNs）、介孔硅 NPs（MSNs）和杂化 NPs（HNs）。我们还讨论了纳米技术在 IV 到口服抗菌治疗发展中的作用，以及 SNPs 用于口服抗菌药物递送的挑战、临床转化和局限性。
