1 Department of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA, USA.
2 The Spinal Cord Research Center, College of Medicine, Drexel University, Philadelphia, PA, USA.
Cell Transplant. 2019 Apr;28(4):388-399. doi: 10.1177/0963689718824097. Epub 2019 Jan 18.
Cellular transplantation for repair of the injured spinal cord has a rich history with strategies focused on neuroprotection, immunomodulation, and neural reconstruction. The goal of the present review is to provide a concise overview and discussion of five key themes that have become important considerations for rebuilding functional neural networks. The questions raised include: (i) who are the donor cells selected for transplantation, (ii) what is the intended target for repair, (iii) when is the optimal time for transplantation, (iv) where should the cells be delivered, and lastly (v) why does cell transplantation remain an attractive candidate for promoting neural repair after injury? Recent developments in neurobiology and engineering now enable us to start addressing these questions with multidisciplinary expertise and methods.
细胞移植修复受损的脊髓有着丰富的历史，其策略主要集中在神经保护、免疫调节和神经重建上。本综述的目的是提供一个简洁的概述和讨论五个关键主题，这些主题已成为重建功能性神经网络的重要考虑因素。提出的问题包括：（i）选择用于移植的供体细胞是谁，（ii）修复的预期目标是什么，（iii）移植的最佳时间是什么时候，（iv）细胞应该输送到哪里，最后（v）为什么细胞移植仍然是促进损伤后神经修复的有吸引力的候选者？神经生物学和工程学的最新发展使我们现在能够利用多学科的专业知识和方法开始解决这些问题。
