IGF1 rs2162679 SNP 的 G 等位基因可能是预防任何类型近视的保护性因素：更新的系统评价和荟萃分析。

The G allele of the IGF1 rs2162679 SNP is a potential protective factor for any myopia: Updated systematic review and meta-analysis.

机构信息

Beijing Friendship Hospital, Capital Medical University, Beijing, China.

出版信息

PLoS One. 2022 Jul 21;17(7):e0271809. doi: 10.1371/journal.pone.0271809. eCollection 2022.

DOI:10.1371/journal.pone.0271809

PMID:35862416

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9302841/

Abstract

BACKGROUND

The insulin-like growth factor 1 (IGF1) gene is located within the myopia-associated MYP3 interval, which suggests it may play an important role in the progression of myopia. However, the association between IGF1 SNPs and any myopia is rarely reported.

METHODS

A comprehensive literature search was conducted on studies published up to July 22, 2021 in PubMed, EMBASE, CBM, COCHRANE, CNKI, WANFANG and VIP databases. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for single-nucleotide polymorphisms (SNPs) that have been evaluated in at least three studies.

RESULTS

Nine studies involving 4596 subjects with any myopia and 4950 controls examined 25 SNPs in IGF1 gene, among which seven SNPs were included in this meta-analysis. Significant associations were not found in any genetic models between rs6214, rs12423791, rs5742632, rs10860862, rs5742629 and any myopia. Rs2162679 was suggestively associated with any myopia in the codominant model (GA vs. AA: OR = 0.87, 95% CI: 0.76-1.00) and the dominant model (GG+GA vs. AA: OR = 0.88, 95% CI = 0.78-1.00).

CONCLUSION

Meta-analysis of updated data reveals that the G allele of the IGF1 rs2162679 SNP is a potential protective factor for any myopia, which is worth further researches.

摘要

背景

胰岛素样生长因子 1（IGF1）基因位于近视相关的 MYP3 区间内，这表明它可能在近视进展中发挥重要作用。然而，IGF1 SNP 与任何近视的关联很少有报道。

方法

系统检索了 2021 年 7 月 22 日之前在 PubMed、EMBASE、CBM、COCHRANE、CNKI、WANFANG 和 VIP 数据库中发表的研究，评估了至少三项研究中评价的单核苷酸多态性（SNP）的比值比（OR）和 95%置信区间（CI）。

结果

纳入了 9 项研究，共涉及 4596 名任何类型近视患者和 4950 名对照，共检测了 IGF1 基因中的 25 个 SNP，其中 7 个 SNP 纳入了本次荟萃分析。在任何遗传模型中，rs6214、rs12423791、rs5742632、rs10860862、rs5742629 与任何近视均无显著关联。在共显性模型（GA 与 AA：OR=0.87，95%CI：0.76-1.00）和显性模型（GG+GA 与 AA：OR=0.88，95%CI=0.78-1.00）中，rs2162679 与任何近视呈提示性关联。