Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea.
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Mental Health Center, Seoul National University Health Care Center, Seoul, Republic of Korea.
J Psychosom Res. 2019 Jan;116:100-105. doi: 10.1016/j.jpsychores.2018.11.015. Epub 2018 Nov 22.
To analyze the longitudinal association between lower urinary tract symptoms (LUTS) and the development of incident depressive symptoms in Korean men.
This study initially recruited 16,155 Korean men who underwent routine health examinations between 2005 and 2012, and completed the International Prostate Symptom Score (IPSS) screening tool and Beck Depression Inventory-1 (BDI). The final study population included 9080 men, aged 15-89, who had a baseline BDI score < 10 and follow-up BDI data, with no history of depression, bladder or prostate operations. Cox proportional hazard models were used to assess the relationship between LUTS and the development of incident depressive symptoms. Multiple imputation was used to handle missing values.
After adjusting for significant covariates, LUTS were associated longitudinally with the development of incident depressive symptoms (hazard ratio [HR] = 1.81 [95% confidence interval [CI] = 1.26-2.61]). An analysis of the specific domains of LUTS revealed that voiding LUTS (HR = 1.58 [95% CI = 1.07-2.33]), but not storage LUTS (HR = 1.43 [95% CI = 0.96-2.13]), were associated longitudinally with depressive symptoms.
LUTS and voiding LUTS, but not storage LUTS, were associated longitudinally with incident depressive symptoms.
分析下尿路症状（LUTS）与韩国男性抑郁症状发生的纵向关联。
本研究最初招募了 16155 名在 2005 年至 2012 年间接受常规健康检查的韩国男性，他们完成了国际前列腺症状评分（IPSS）筛查工具和贝克抑郁量表-1（BDI）。最终研究人群包括 9080 名年龄在 15 至 89 岁之间的男性，他们在基线时 BDI 评分<10 且有随访 BDI 数据，且无抑郁、膀胱或前列腺手术史。使用 Cox 比例风险模型评估 LUTS 与新发抑郁症状之间的关系。使用多重插补处理缺失值。
在调整了显著协变量后，LUTS 与新发抑郁症状的发生呈纵向相关（风险比 [HR] = 1.81 [95%置信区间 [CI] = 1.26-2.61]）。对 LUTS 特定领域的分析表明，排尿症状（HR = 1.58 [95% CI = 1.07-2.33]），而不是存储症状（HR = 1.43 [95% CI = 0.96-2.13]），与抑郁症状呈纵向相关。
LUTS 和排尿症状，而不是存储症状，与新发抑郁症状呈纵向相关。
