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Hypoxia attenuates inflammation-induced hepcidin synthesis during experimental human endotoxemia.

作者信息

Kiers Dorien, van Eijk Lucas T, van der Hoeven Johannes G, Swinkels Dorine W, Pickkers Peter, Kox Matthijs

机构信息

Department of Intensive Care Medicine, Radboud University Medical Center.

Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center.

出版信息

Haematologica. 2019 Jun;104(6):e230-e232. doi: 10.3324/haematol.2018.202796. Epub 2019 Jan 17.

DOI:10.3324/haematol.2018.202796
PMID:30655372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6545842/
Abstract
摘要

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本文引用的文献

1
Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation.短期缺氧通过增强腺苷释放和腺苷 2B 受体刺激来抑制体内炎症反应。
EBioMedicine. 2018 Jul;33:144-156. doi: 10.1016/j.ebiom.2018.06.021. Epub 2018 Jul 4.
2
Advances in understanding iron metabolism and its crosstalk with erythropoiesis.理解铁代谢及其与红细胞生成相互作用的进展。
Br J Haematol. 2018 Aug;182(4):481-494. doi: 10.1111/bjh.15403. Epub 2018 Jun 25.
3
Clinical Trial of Vadadustat in Patients with Anemia Secondary to Stage 3 or 4 Chronic Kidney Disease.达泊西汀治疗3或4期慢性肾脏病继发贫血患者的临床试验。
Am J Nephrol. 2017;45(5):380-388. doi: 10.1159/000464476. Epub 2017 Mar 25.
4
Iron Balance and the Role of Hepcidin in Chronic Kidney Disease.铁平衡与铁调素在慢性肾脏病中的作用
Semin Nephrol. 2016 Mar;36(2):87-93. doi: 10.1016/j.semnephrol.2016.02.001.
5
Revisiting STAT3 signalling in cancer: new and unexpected biological functions.重新审视 STAT3 信号通路在癌症中的作用：新的、意想不到的生物学功能。
Nat Rev Cancer. 2014 Nov;14(11):736-46. doi: 10.1038/nrc3818.
6
Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans.抗铁调素 Spiegelmer 药物 lexaptepid 对炎症诱导的人体血清铁降低的影响。
Blood. 2014 Oct 23;124(17):2643-6. doi: 10.1182/blood-2014-03-559484. Epub 2014 Aug 27.
7
Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB.缺氧诱导的铁调素下调是由血小板衍生生长因子 BB 介导的。
Gut. 2014 Dec;63(12):1951-9. doi: 10.1136/gutjnl-2013-305317. Epub 2014 Mar 5.
8
The effect of iron loading and iron chelation on the innate immune response and subclinical organ injury during human endotoxemia: a randomized trial.铁负荷与铁螯合对人类内毒素血症期间先天性免疫反应及亚临床器官损伤的影响：一项随机试验。
Haematologica. 2014 Mar;99(3):579-87. doi: 10.3324/haematol.2013.088047. Epub 2013 Nov 15.
9
Manipulation of the hepcidin pathway for therapeutic purposes.针对治疗目的对铁调素途径的操控。
Haematologica. 2013 Nov;98(11):1667-76. doi: 10.3324/haematol.2013.084624.
10
Erythrocytosis: the HIF pathway in control.红细胞增多症：HIF 通路的控制作用。
Blood. 2013 Aug 15;122(7):1122-8. doi: 10.1182/blood-2013-01-478065. Epub 2013 Jun 3.