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日本的辅助生殖技术:日本妇产科学会伦理委员会2016年总结报告

Assisted reproductive technology in Japan: A summary report for 2016 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology.

作者信息

Ishihara Osamu, Jwa Seung Chik, Kuwahara Akira, Ishikawa Tomonori, Kugu Koji, Sawa Rintaro, Banno Kouji, Irahara Minoru, Saito Hidekazu

机构信息

Department of Obstetrics and Gynecology Saitama Medical University Saitama Japan.

Department of Obstetrics and Gynecology, Graduate School of Biomedical Sciences Tokushima University Tokushima Japan.

出版信息

Reprod Med Biol. 2018 Nov 29;18(1):7-16. doi: 10.1002/rmb2.12258. eCollection 2019 Jan.

Abstract

PURPOSE

The Japan Society of Obstetrics and Gynecology started an online cycle-based assisted reproductive technology (ART) registry system in 2007. This report presents the characteristics and treatment outcomes of ART registered for the cycles practiced during 2016.

METHODS

Cycle-specific information for all ART cycles implemented in participating ART facilities were collected. A descriptive analysis was conducted for the registry database of 2016.

RESULTS

In total, 447 790 treatment cycles and 54 110 neonates (one in 18.1 neonates born in Japan) were reported in 2016. The mean patients' age was 38.1 years (SD = 4.5). Among the egg retrieval cycles, 104 575 of 251 399 (41.6%) were freeze-all cycles without fresh embryo transfers (ET), while fresh ET was performed in 64 497 cycles (58.4%). A total of 187 132 frozen-thawed ET cycles were reported, resulting in 62 432 pregnancies and 44 484 neonates born. Single ET was selected for 81.0% of fresh transfers and 82.7% of frozen cycles, resulting in singleton pregnancy/live birth rates of 97.0%/96.4% and 96.7%/96.4%, respectively.

CONCLUSION

The total ART cycles and subsequent live births continued to increase in 2016. Single ET was performed more than 80%, and ET has shifted from using fresh embryos to frozen ones.

摘要

目的

日本妇产科学会于2007年启动了一个基于周期的辅助生殖技术(ART)在线登记系统。本报告介绍了2016年登记的ART周期的特征和治疗结果。

方法

收集了参与ART机构实施的所有ART周期的特定周期信息。对2016年的登记数据库进行了描述性分析。

结果

2016年共报告了447790个治疗周期和54110例新生儿(占日本出生新生儿的十八分之一)。患者的平均年龄为38.1岁(标准差=4.5)。在取卵周期中,251399个周期中有104575个(41.6%)为全冷冻周期,未进行新鲜胚胎移植(ET),而64497个周期(58.4%)进行了新鲜ET。共报告了187132个冻融ET周期,产生了62432例妊娠和44484例新生儿出生。81.0%的新鲜移植和82.7%的冷冻周期选择了单胚胎移植,单胎妊娠/活产率分别为97.0%/96.4%和96.7%/96.4%。

结论

2016年ART周期总数及随后的活产数持续增加。单胚胎移植的比例超过80%,并且胚胎移植已从使用新鲜胚胎转向使用冷冻胚胎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d302/6332769/25a73d6d8a59/RMB2-18-7-g001.jpg

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