Qi Dongdong, Wang Qiang, Wu Meiqing, Zhang Xiong
Department of Clinical Laboratory, Hulunbuir Mental Health Center, Hulunbuir, Inner Mongolia 022150, P.R. China.
Department of General Surgery, Inner Mongolia Forestry General Hospital, Hulunbuir, Inner Mongolia 022150, P.R. China.
Oncol Lett. 2019 Jan;17(1):1279-1291. doi: 10.3892/ol.2018.9707. Epub 2018 Nov 15.
Long non-coding RNAs (lncRNAs) have been generally considered to serve important roles in various types of cancer, including gastric cancer. However, a comprehensive understanding of lncRNAs in gastric cancer requires further study. The present study performed an in-depth study revealed 50 differently expressed lncRNAs. The changed cellular pathways and biological process in gastric cancer were determined. To further confirm the functions of the differently expressed lncRNAs, co-expression networks were constructed between the lncRNAs and mRNA; this lead to the identification of 6 modules, which participated in various cellular pathways. In addition, 2 lncRNAs were identified which were associated with clinical outcome. The biological analysis and experimental evidence suggested that LINC00982 inhibited, while LL22NC03-N14H11.1 promoted the proliferation of gastric cancer cells. These lncRNAs may be considered as potential prognostic factor in gastric cancer.
长链非编码RNA（lncRNAs）通常被认为在包括胃癌在内的各种癌症类型中发挥重要作用。然而，对胃癌中lncRNAs的全面了解还需要进一步研究。本研究进行了深入研究，发现了50种差异表达的lncRNAs。确定了胃癌中细胞途径和生物学过程的变化。为了进一步证实差异表达lncRNAs的功能，构建了lncRNAs与mRNA之间的共表达网络；这导致识别出6个模块，它们参与了各种细胞途径。此外，还鉴定出2种与临床结果相关的lncRNAs。生物学分析和实验证据表明，LINC00982抑制胃癌细胞增殖，而LL22NC03-N14H11.1促进胃癌细胞增殖。这些lncRNAs可能被视为胃癌潜在的预后因素。
