Nanda Anil, Baptist Alan P, Divekar Rohit, Parikh Neil, Seggev Joram S, Yusin Joseph S, Nyenhuis Sharmilee M
Asthma and Allergy Center, Lewisville and Flower Mound, TX, USA.
Division of Allergy and Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
J Asthma. 2020 Mar;57(3):241-252. doi: 10.1080/02770903.2019.1565828. Epub 2019 Jan 18.
The older adult population is increasing worldwide, and a significant percentage has asthma. This review will discuss the challenges to diagnosis and management of asthma in older adults. : PubMed was searched for multiple terms in various combinations, including asthma, older adult, elderly, comorbid conditions, asthma diagnosis, asthma treatment, biologics and medication side effects, and adverse events. From the search, the data sources that were utilized included peer reviewed scholarly review articles, peer reviewed scientific research articles, and peer reviewed book chapters. : Study selections that were utilized included peer reviewed scholarly review articles, peer reviewed scientific research articles, and peer reviewed book chapters. : Asthma in older adults is frequently underdiagnosed and has higher morbidity and mortality rates compared to their younger counterparts. A detailed history and physical examination as well as judicious testing are essential to establish the asthma diagnosis and exclude alternative ones. Medical comorbidities, such as cardiovascular disease, cognitive impairment, depression, arthritis, gastroesophageal reflux disease (GERD), rhinitis, and sinusitis are common in this population and should also be assessed and treated. Non-pharmacologic management, including asthma education on inhaler technique and self-monitoring, is vital. Pharmacologic management includes standard asthma therapies such as inhaled corticosteroids (ICS), inhaled corticosteroid-long acting β-agonist combinations (ICS-LABA), leukotriene antagonists, long acting muscarinic antagonists (LAMA), and short acting bronchodilators (SABA). Newly approved biologic agents may also be utilized. Older adults are more vulnerable to polypharmacy and medication adverse events, and this should be taken into account when selecting the appropriate asthma treatment. : The diagnosis and management of asthma in older adults has certain challenges, but if the clinician is aware of them, the morbidity and mortality of this condition can be improved in this growing population.
全球老年人口数量正在增加,其中相当一部分患有哮喘。本综述将讨论老年哮喘诊断和管理面临的挑战。:在PubMed中使用多种组合词进行检索,包括哮喘、老年人、年长者、合并症、哮喘诊断、哮喘治疗、生物制剂和药物副作用以及不良事件。通过检索,所利用的数据来源包括同行评审的学术综述文章、同行评审的科学研究文章以及同行评审的书籍章节。:所采用的研究选择包括同行评审的学术综述文章、同行评审的科学研究文章以及同行评审的书籍章节。:老年哮喘常常诊断不足,与年轻患者相比,其发病率和死亡率更高。详细的病史和体格检查以及审慎的检查对于确立哮喘诊断并排除其他疾病至关重要。该人群中常见心血管疾病、认知障碍、抑郁症、关节炎、胃食管反流病(GERD)、鼻炎和鼻窦炎等内科合并症,也应进行评估和治疗。非药物管理,包括关于吸入器技术和自我监测的哮喘教育,至关重要。药物管理包括标准的哮喘治疗方法,如吸入性糖皮质激素(ICS)、吸入性糖皮质激素 - 长效β受体激动剂联合制剂(ICS - LABA)、白三烯拮抗剂、长效毒蕈碱拮抗剂(LAMA)和短效支气管扩张剂(SABA)。新批准的生物制剂也可使用。老年人更容易出现多重用药和药物不良事件,在选择合适的哮喘治疗方法时应考虑到这一点。:老年哮喘的诊断和管理存在一定挑战,但如果临床医生了解这些挑战,在这个不断增长的人群中,这种疾病的发病率和死亡率是可以改善的。