Giordano Davide, Castellucci Andrea, Merli Francesco, Garlassi Elisa, Pernice Carmine
Otolaryngology Unit, Department of Surgery, Arcispedale Santa Maria Nuova-IRCCS.
Acta Biomed. 2019 Jan 15;89(4):576-580. doi: 10.23750/abm.v89i4.6627.
HIV-related Burkitt's lymphoma with initial oropharyngeal presentation is rarely reported. The aim of this paper is to report the clinical findings of an unusual case of a patient with extranodal oropharyngeal Burkitt's lymphoma as presenting disease of an unknown HIV positivity and acquired immunodeficiency syndrome.
We reported the case of a hispanic patient with extranodal oropharyngeal Burkitt's lymphoma as presenting disease of an unknown HIV positivity and acquired immunodeficiency syndrome. We describe the diagnostic work-up and treatment of this rare case of extranodal oropharyngeal Burkitt's lymphoma.
Histological exam on oropharyngeal incision biopsy documented a Burkitt's lymphoma. The patient underwent highly active antiretroviral therapy and chemotherapy. After two years of follow-up the patient shows no signs of recurrence from disease.
HIV-related Burkitt's lymphoma presenting with primary oropharyngeal involvement is rare, with rapidly progressing dysphagia, and does not respond to antibiotherapy. Patients should undergo incision biopsy to rule out a malignancy. In young adults, diagnosis of Burkitt's lymphoma should suggest HIV infection. The importance of a prompt diagnosis in such cases is essential to correctly adequately staging the disease to start highly active antiretroviral therapy and chemotherapy as soon as possible.
初始表现为口咽症状的与HIV相关的伯基特淋巴瘤鲜有报道。本文旨在报告一例罕见病例的临床发现，该患者为结外口咽伯基特淋巴瘤，初诊时HIV感染状态及是否患有获得性免疫缺陷综合征均未知。
我们报告了一例西班牙裔患者，其结外口咽伯基特淋巴瘤为初诊疾病，HIV感染状态及是否患有获得性免疫缺陷综合征均未知。我们描述了这例罕见的结外口咽伯基特淋巴瘤的诊断检查及治疗过程。
口咽切口活检的组织学检查证实为伯基特淋巴瘤。患者接受了高效抗逆转录病毒治疗及化疗。经过两年随访，患者无疾病复发迹象。
以原发性口咽受累为表现的与HIV相关的伯基特淋巴瘤较为罕见，吞咽困难进展迅速，对抗生素治疗无反应。患者应接受切口活检以排除恶性肿瘤。在年轻成人中，伯基特淋巴瘤的诊断应提示HIV感染。在此类病例中及时诊断对于正确充分地对疾病进行分期至关重要，以便尽快开始高效抗逆转录病毒治疗及化疗。
