神经母细胞瘤：肿瘤生物学及其对分期和治疗的影响

Van Arendonk Kyle J, Chung Dai H

Department of Surgery, Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Department of Surgery, Children's Medical Center Dallas, UT Southwestern Medical Center, Dallas, TX 75235, USA.

Children (Basel). 2019 Jan 17;6(1):12. doi: 10.3390/children6010012.

Neuroblastoma, the most common extracranial solid tumor of childhood, has widely variable outcomes dependent on the specific biology of the tumor. In this review, current biologic principles that are used to stratify risk and guide treatment algorithms are discussed. The role for surgical resection in neuroblastoma is also reviewed, including the indications and timing of surgery within the greater treatment plan.

神经母细胞瘤是儿童最常见的颅外实体瘤，其预后因肿瘤的特定生物学特性而有很大差异。在本综述中，讨论了用于风险分层和指导治疗方案的当前生物学原理。还回顾了手术切除在神经母细胞瘤中的作用，包括在更大的治疗计划中手术的适应症和时机。