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Reduced efficacy of low FODMAPs diet in patients with IBS-D carrying sucrase-isomaltase () hypomorphic variants.

作者信息

Zheng Tenghao, Eswaran Shanti, Photenhauer Amanda L, Merchant Juanita L, Chey William D, D'Amato Mauro

机构信息

Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

出版信息

Gut. 2020 Feb;69(2):397-398. doi: 10.1136/gutjnl-2018-318036. Epub 2019 Jan 18.

DOI:10.1136/gutjnl-2018-318036
PMID:30658996
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6984052/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25dc/6984052/e630ce8fed3b/gutjnl-2018-318036f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25dc/6984052/e630ce8fed3b/gutjnl-2018-318036f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25dc/6984052/e630ce8fed3b/gutjnl-2018-318036f01.jpg

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Reduced efficacy of low FODMAPs diet in patients with IBS-D carrying sucrase-isomaltase () hypomorphic variants.低FODMAP饮食对携带蔗糖酶-异麦芽糖酶（）低表达变体的腹泻型肠易激综合征患者疗效降低。
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本文引用的文献

1
The role of diet in the management of irritable bowel syndrome: a focus on FODMAPs.饮食在肠易激综合征管理中的作用：关注 FODMAP。
Expert Rev Gastroenterol Hepatol. 2018 Jun;12(6):607-615. doi: 10.1080/17474124.2018.1476138. Epub 2018 May 18.
2
Increased Prevalence of Rare Sucrase-isomaltase Pathogenic Variants in Irritable Bowel Syndrome Patients.肠易激综合征患者中罕见的蔗糖-异麦芽糖酶病 因变异的流行率增加。
Clin Gastroenterol Hepatol. 2018 Oct;16(10):1673-1676. doi: 10.1016/j.cgh.2018.01.047. Epub 2018 Feb 21.
3
Sucrase-isomaltase 15Phe IBS risk variant in relation to dietary carbohydrates and faecal microbiota composition.
肠道-脑互动障碍饮食疗法的创新理念
JGH Open. 2024 Jul 18;8(7):e70001. doi: 10.1002/jgh3.70001. eCollection 2024 Jul.
4
Human CAZyme genes polymorphism and risk of IBS: a population-based study.人类碳水化合物活性酶基因多态性与肠易激综合征风险：一项基于人群的研究。
Gut. 2025 Jan 17;74(2):329-331. doi: 10.1136/gutjnl-2024-333056.
5
Nutrition and Disorders of Gut-Brain Interaction.营养与肠道-脑相互作用障碍。
Nutrients. 2024 Jan 4;16(1):176. doi: 10.3390/nu16010176.
6
A 1 year course of starch- and sucrose-reduced diet used by irritable bowel syndrome patients with diarrhoea and the effect of genetic variants.腹泻型肠易激综合征患者采用的为期1年的低淀粉和低蔗糖饮食方案及其基因变异的影响。
Front Nutr. 2023 Oct 26;10:1268538. doi: 10.3389/fnut.2023.1268538. eCollection 2023.
7
Intestinal Disaccharidase Deficiency in Adults: Evaluation and Treatment.成人肠双糖酶缺乏症：评估与治疗。
Curr Gastroenterol Rep. 2023 Jun;25(6):134-139. doi: 10.1007/s11894-023-00870-z. Epub 2023 May 18.
8
Sucrase-isomaltase genotype and response to a starch-reduced and sucrose-reduced diet in IBS-D patients.蔗糖酶-异麦芽糖酶基因型与腹泻型肠易激综合征患者对低淀粉和低蔗糖饮食的反应
Gut. 2024 Mar 7;73(4):706-708. doi: 10.1136/gutjnl-2023-329695.
9
Sucrose intolerance in adults with common functional gastrointestinal symptoms.有常见功能性胃肠症状的成年人中的蔗糖不耐受
Proc (Bayl Univ Med Cent). 2022 Aug 23;35(6):790-793. doi: 10.1080/08998280.2022.2114070. eCollection 2022.
10
Application of The FODMAP Diet in a Paediatric Setting.在儿科环境中应用 FODMAP 饮食。
Nutrients. 2022 Oct 18;14(20):4369. doi: 10.3390/nu14204369.
蔗糖酶-异麦芽糖酶15Phe肠易激综合征风险变异与膳食碳水化合物及粪便微生物群组成的关系
Gut. 2019 Jan;68(1):177-178. doi: 10.1136/gutjnl-2017-315841. Epub 2018 Jan 13.
4
Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome.蔗糖酶-异麦芽糖酶基因中的功能性变异与肠易激综合征风险增加相关。
Gut. 2018 Feb;67(2):263-270. doi: 10.1136/gutjnl-2016-312456. Epub 2016 Nov 21.
5
A Randomized Controlled Trial Comparing the Low FODMAP Diet vs. Modified NICE Guidelines in US Adults with IBS-D.一项比较低FODMAP饮食与改良版英国国家卫生与临床优化研究所（NICE）指南对美国患有腹泻型肠易激综合征（IBS-D）成年人疗效的随机对照试验。
Am J Gastroenterol. 2016 Dec;111(12):1824-1832. doi: 10.1038/ajg.2016.434. Epub 2016 Oct 11.
6
The multiple roles of sucrase-isomaltase in the intestinal physiology.蔗糖酶-异麦芽糖酶在肠道生理学中的多种作用。
Mol Cell Pediatr. 2016 Dec;3(1):2. doi: 10.1186/s40348-016-0033-y. Epub 2016 Jan 26.
7
Sensitivity to wheat, gluten and FODMAPs in IBS: facts or fiction?IBS 患者对小麦、麸质和 FODMAPs 的敏感性：事实还是虚构？
Gut. 2016 Jan;65(1):169-78. doi: 10.1136/gutjnl-2015-309757. Epub 2015 Jun 15.