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Sucrase-isomaltase genotype and response to a starch-reduced and sucrose-reduced diet in IBS-D patients.

作者信息

Zamfir-Taranu Andreea, Löscher Britt-Sabina, Husein Diab M, Hoter Abdullah, Garcia-Etxebarria Koldo, Etxeberria Usune, Gayoso Lucía, Mayr Gabriele, Nilholm Clara, Gustafsson Rita J, Ozaydin Oliver, Zheng Tenghao, Esteban-Blanco Cristina, Bozzarelli Isotta, Bonfiglio Ferdinando, Rizk Sandra, Franke Andre, Bujanda Luis, Naim Hassan Y, Ohlsson Bodil, D'Amato Mauro

机构信息

Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain.

Institute of Clinical Molecular Biology, Kiel University and University Medical Center Schleswig-Holstein, Kiel, Germany.

出版信息

Gut. 2024 Mar 7;73(4):706-708. doi: 10.1136/gutjnl-2023-329695.

DOI:10.1136/gutjnl-2023-329695
PMID:36878682
原文链接:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10958263/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9758/10958263/df7d6eb0cf9d/gutjnl-2023-329695f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9758/10958263/df7d6eb0cf9d/gutjnl-2023-329695f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9758/10958263/df7d6eb0cf9d/gutjnl-2023-329695f01.jpg

相似文献

1
Sucrase-isomaltase genotype and response to a starch-reduced and sucrose-reduced diet in IBS-D patients.蔗糖酶-异麦芽糖酶基因型与腹泻型肠易激综合征患者对低淀粉和低蔗糖饮食的反应
Gut. 2024 Mar 7;73(4):706-708. doi: 10.1136/gutjnl-2023-329695.
2
Impaired cell surface expression and digestive function of sucrase-isomaltase gene variants are associated with reduced efficacy of low FODMAPs diet in patients with IBS-D.蔗糖酶-异麦芽糖酶基因变异体的细胞表面表达受损和消化功能与腹泻型肠易激综合征患者低FODMAP饮食疗效降低有关。
Gut. 2020 Aug;69(8):1538-1539. doi: 10.1136/gutjnl-2019-319411. Epub 2019 Jul 22.
3
Sucrase-isomaltase 15Phe IBS risk variant in relation to dietary carbohydrates and faecal microbiota composition.蔗糖酶-异麦芽糖酶15Phe肠易激综合征风险变异与膳食碳水化合物及粪便微生物群组成的关系
Gut. 2019 Jan;68(1):177-178. doi: 10.1136/gutjnl-2017-315841. Epub 2018 Jan 13.
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Differential Effects of Sucrase-Isomaltase Mutants on Its Trafficking and Function in Irritable Bowel Syndrome: Similarities to Congenital Sucrase-Isomaltase Deficiency.肠易激综合征中蔗糖酶-异麦芽糖酶突变体对其运输和功能的差异影响：与先天性蔗糖酶-异麦芽糖酶缺乏的相似性。
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Reduced efficacy of low FODMAPs diet in patients with IBS-D carrying sucrase-isomaltase () hypomorphic variants.低FODMAP饮食对携带蔗糖酶-异麦芽糖酶（）低表达变体的腹泻型肠易激综合征患者疗效降低。
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Severe pathogenic variants of intestinal sucrase-isomaltase interact avidly with the wild type enzyme and negatively impact its function and trafficking.肠道蔗糖酶-异麦芽糖酶的严重致病性变异体与野生型酶强烈相互作用，从而对其功能和运输产生负面影响。
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Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome.蔗糖酶-异麦芽糖酶基因中的功能性变异与肠易激综合征风险增加相关。
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Increased Prevalence of Rare Sucrase-isomaltase Pathogenic Variants in Irritable Bowel Syndrome Patients.肠易激综合征患者中罕见的蔗糖-异麦芽糖酶病 因变异的流行率增加。
Clin Gastroenterol Hepatol. 2018 Oct;16(10):1673-1676. doi: 10.1016/j.cgh.2018.01.047. Epub 2018 Feb 21.
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Theories behind the effect of starch‑ and sucrose‑reduced diets on gastrointestinal symptoms in irritable bowel syndrome (Review).淀粉和蔗糖减少饮食对肠易激综合征胃肠道症状影响的理论（综述）。
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Congenital sucrase-isomaltase deficiency: heterogeneity of inheritance, trafficking, and function of an intestinal enzyme complex.先天性蔗糖酶-异麦芽糖酶缺乏症：肠道酶复合物遗传、转运及功能的异质性
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Human CAZyme genes polymorphism and risk of IBS: a population-based study.人类碳水化合物活性酶基因多态性与肠易激综合征风险：一项基于人群的研究。
Gut. 2025 Jan 17;74(2):329-331. doi: 10.1136/gutjnl-2024-333056.
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The gut microbiome in disorders of gut-brain interaction.肠-脑相互作用障碍中的肠道微生物组。
Gut Microbes. 2024 Jan-Dec;16(1):2360233. doi: 10.1080/19490976.2024.2360233. Epub 2024 Jul 1.
3
Genotype-informed nutrition counselling in clinical practice.临床实践中的基因信息指导营养咨询。

本文引用的文献

1
The effect of starch- and sucrose-reduced diet accompanied by nutritional and culinary recommendations on the symptoms of irritable bowel syndrome patients with diarrhoea.减少淀粉和蔗糖摄入的饮食并辅以营养及烹饪建议对腹泻型肠易激综合征患者症状的影响
Therap Adv Gastroenterol. 2023 Apr 28;16:17562848231156682. doi: 10.1177/17562848231156682. eCollection 2023.
2
Irritable bowel syndrome: treatment based on pathophysiology and biomarkers.肠易激综合征：基于病理生理学和生物标志物的治疗。
Gut. 2023 Mar;72(3):590-599. doi: 10.1136/gutjnl-2022-328515. Epub 2022 Oct 28.
3
The FODMAP diet: more than just a symptomatic therapy?
BMJ Nutr Prev Health. 2023 Dec 27;6(2):407-412. doi: 10.1136/bmjnph-2023-000808. eCollection 2023.
4
Nutrition and Disorders of Gut-Brain Interaction.营养与肠道-脑相互作用障碍。
Nutrients. 2024 Jan 4;16(1):176. doi: 10.3390/nu16010176.
5
A 1 year course of starch- and sucrose-reduced diet used by irritable bowel syndrome patients with diarrhoea and the effect of genetic variants.腹泻型肠易激综合征患者采用的为期1年的低淀粉和低蔗糖饮食方案及其基因变异的影响。
Front Nutr. 2023 Oct 26;10:1268538. doi: 10.3389/fnut.2023.1268538. eCollection 2023.
低聚半乳糖、双糖、单糖和多元醇饮食：仅仅是对症治疗吗？
Gut. 2022 Sep;71(9):1693-1694. doi: 10.1136/gutjnl-2021-326284. Epub 2021 Nov 22.
4
Rome Foundation Clinical Diagnostic Criteria for Disorders of Gut-Brain Interaction.罗马基金会肠道-脑互动障碍临床诊断标准。
Gastroenterology. 2022 Mar;162(3):675-679. doi: 10.1053/j.gastro.2021.11.019. Epub 2021 Nov 19.
5
Adult sucrase-isomaltase deficiency masquerading as IBS.成人蔗糖酶-异麦芽糖酶缺乏症伪装成肠易激综合征。
Gut. 2022 Jun;71(6):1237-1238. doi: 10.1136/gutjnl-2021-326153. Epub 2021 Oct 6.
6
Rare Hypomorphic Sucrase Isomaltase Variants in Relation to Irritable Bowel Syndrome Risk in UK Biobank.英国生物银行中与肠易激综合征风险相关的罕见低表达蔗糖酶异麦芽糖酶变体
Gastroenterology. 2021 Nov;161(5):1712-1714. doi: 10.1053/j.gastro.2021.06.063. Epub 2021 Jun 26.
7
A Dietary Intervention with Reduction of Starch and Sucrose Leads to Reduced Gastrointestinal and Extra-Intestinal Symptoms in IBS Patients.膳食纤维干预减少淀粉和蔗糖可减轻 IBS 患者的胃肠道和肠外症状。
Nutrients. 2019 Jul 20;11(7):1662. doi: 10.3390/nu11071662.
8
Reduced efficacy of low FODMAPs diet in patients with IBS-D carrying sucrase-isomaltase () hypomorphic variants.低FODMAP饮食对携带蔗糖酶-异麦芽糖酶（）低表达变体的腹泻型肠易激综合征患者疗效降低。
Gut. 2020 Feb;69(2):397-398. doi: 10.1136/gutjnl-2018-318036. Epub 2019 Jan 18.
9
Increased Prevalence of Rare Sucrase-isomaltase Pathogenic Variants in Irritable Bowel Syndrome Patients.肠易激综合征患者中罕见的蔗糖-异麦芽糖酶病 因变异的流行率增加。
Clin Gastroenterol Hepatol. 2018 Oct;16(10):1673-1676. doi: 10.1016/j.cgh.2018.01.047. Epub 2018 Feb 21.
10
Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome.蔗糖酶-异麦芽糖酶基因中的功能性变异与肠易激综合征风险增加相关。
Gut. 2018 Feb;67(2):263-270. doi: 10.1136/gutjnl-2016-312456. Epub 2016 Nov 21.