没有脑血清素的成年Tph2基因敲除小鼠的脊柱小梁骨适度增加，但皮质骨厚度适度降低。
Adult Tph2 knockout mice without brain serotonin have moderately elevated spine trabecular bone but moderately low cortical bone thickness.
作者信息
Brommage Robert, Liu Jeff, Doree Deon, Yu Wangsheng, Powell David R, Melissa Yang Qi
机构信息
Lexicon Pharmaceuticals , The Woodlands, TX, USA.
出版信息
Bonekey Rep. 2015 Jul 15;4:718. doi: 10.1038/bonekey.2015.87. eCollection 2015.
Abstract
Disruption of serotonin synthesis in neurons and the periphery by knockout (KO) of mouse genes for tryptophan hydroxylases (peripheral Tph1 and neuronal Tph2) has been claimed to decrease (Tph2 KO) and increase (Tph1 KO) bone mass. In this report, adult male and female Tph2 KO mice were observed to have elevated spine trabecular bone. Female Tph2 KO mice have reduced midshaft femur cortical bone thickness. Bone mass was normal in male and female Tph1 KO mice examined as part of a Tph1/Tph2 double knockout (DKO) mouse cohort.
摘要
据宣称，通过敲除小鼠色氨酸羟化酶基因（外周Tph1和神经元Tph2）来破坏神经元和外周的5-羟色胺合成，会导致骨量减少（Tph2基因敲除）和增加（Tph1基因敲除）。在本报告中，观察到成年雄性和雌性Tph2基因敲除小鼠的脊柱小梁骨增加。雌性Tph2基因敲除小鼠的股骨干中部皮质骨厚度减小。作为Tph1/Tph2双基因敲除（DKO）小鼠队列的一部分进行检测的雄性和雌性Tph1基因敲除小鼠的骨量正常。
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