Department of Microbiology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-067 Bydgoszcz, Poland.
Department of Food Hygiene and Consumer Health, Wrocław University of Environmental and Life Sciences, 50-375 Wrocław, Poland.
Int J Mol Sci. 2022 Jul 15;23(14):7820. doi: 10.3390/ijms23147820.
Stress and anxiety are common phenomena that contribute to many nervous system dysfunctions. More and more research has been focusing on the importance of the gut-brain axis in the course and treatment of many diseases, including nervous system disorders. This review aims to present current knowledge on the influence of psychobiotics on the gut-brain axis based on selected diseases, i.e., Alzheimer's disease, Parkinson's disease, depression, and autism spectrum disorders. Analyses of the available research results have shown that selected probiotic bacteria affect the gut-brain axis in healthy people and people with selected diseases. Furthermore, supplementation with probiotic bacteria can decrease depressive symptoms. There is no doubt that proper supplementation improves the well-being of patients. Therefore, it can be concluded that the intestinal microbiota play a relevant role in disorders of the nervous system. The microbiota-gut-brain axis may represent a new target in the prevention and treatment of neuropsychiatric disorders. However, this topic needs more research. Such research could help find effective treatments via the modulation of the intestinal microbiome.
压力和焦虑是常见的现象，会导致许多神经系统功能障碍。越来越多的研究关注肠道-大脑轴在许多疾病（包括神经系统疾病）的发生和治疗中的重要性。本综述旨在根据选定的疾病，即阿尔茨海默病、帕金森病、抑郁症和自闭症谱系障碍，介绍关于心理益生菌对肠道-大脑轴影响的最新知识。对现有研究结果的分析表明，选定的益生菌会影响健康人群和特定疾病患者的肠道-大脑轴。此外，益生菌补充剂可以减轻抑郁症状。毫无疑问，适当的补充可以改善患者的幸福感。因此，可以得出结论，肠道微生物群在神经系统疾病中起重要作用。微生物群-肠道-大脑轴可能代表神经精神障碍预防和治疗的新靶点。然而，这个话题需要更多的研究。这种研究可以通过调节肠道微生物组来帮助找到有效的治疗方法。
