小梁网细胞是青光眼细胞治疗的宝贵资源。
Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma.
机构信息
Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Ophthalmology, the Second People's Hospital of Yunnan Province (Fourth Affiliated Hospital of Kunming Medical University), Yunnan Eye Institute, Key Laboratory of Yunnan Province for the Prevention and Treatment of Ophthalmology (2017DG008), Provincial Innovation Team for Cataract and Ocular Fundus Disease, The Second People's Hospital of Yunnan Province (2017HC010), Expert Workstation of Yao Ke (2017IC064), Kunming, China.
出版信息
J Cell Mol Med. 2019 Mar;23(3):1678-1686. doi: 10.1111/jcmm.14158. Epub 2019 Jan 18.
Abstract
Trabecular meshwork (TM) contains a subset of adult stem cells or progenitors that can be differentiated into corneal endothelial cells, adipocytes and chondrocytes, but not osteocytes or keratocytes. Accordingly, these progenitors can be utilized as a cell-based therapy to prevent blindness caused by glaucoma, corneal endothelial dysfunction and other diseases in general. In this review, we review in vitro expansion techniques for TM progenitors, discuss their phenotypic properties, and highlight their potential clinical applications in various ophthalmic diseases.
摘要
小梁网（TM）包含一组成人干细胞或祖细胞，这些细胞可分化为角膜内皮细胞、脂肪细胞和成软骨细胞，但不能分化为成骨细胞或角膜细胞。因此，这些祖细胞可以用作基于细胞的治疗方法，以预防青光眼、角膜内皮功能障碍和其他一般疾病引起的失明。在这篇综述中，我们回顾了 TM 祖细胞的体外扩增技术，讨论了它们的表型特性，并强调了它们在各种眼科疾病中的潜在临床应用。
相似文献
1
Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma.小梁网细胞是青光眼细胞治疗的宝贵资源。
J Cell Mol Med. 2019 Mar;23(3):1678-1686. doi: 10.1111/jcmm.14158. Epub 2019 Jan 18.
2
Human Trabecular Meshwork Progenitors.人眼小梁网祖细胞。
Int J Med Sci. 2019 May 10;16(5):704-710. doi: 10.7150/ijms.32089. eCollection 2019.
3
Progenitors for the corneal endothelium and trabecular meshwork: a potential source for personalized stem cell therapy in corneal endothelial diseases and glaucoma.角膜内皮细胞和小梁网的祖细胞：角膜内皮疾病和青光眼个性化干细胞治疗的潜在来源。
J Biomed Biotechnol. 2011;2011:412743. doi: 10.1155/2011/412743. Epub 2011 Dec 6.
4
Cell-Based Therapies for Trabecular Meshwork Regeneration to Treat Glaucoma.基于细胞的小梁网再生疗法治疗青光眼。
Biomolecules. 2021 Aug 24;11(9):1258. doi: 10.3390/biom11091258.
5
Isolation and Expansion of Multipotent Progenitors from Human Trabecular Meshwork.人眼小梁组织多能祖细胞的分离和扩增。
Sci Rep. 2018 Feb 12;8(1):2814. doi: 10.1038/s41598-018-21098-2.
6
Two-step induction of trabecular meshwork cells from induced pluripotent stem cells for glaucoma.两步法诱导诱导多能干细胞分化为小梁网细胞用于青光眼。
Biochem Biophys Res Commun. 2020 Aug 20;529(2):411-417. doi: 10.1016/j.bbrc.2020.05.225. Epub 2020 Jul 1.
7
Identification and application of p75 neurotrophin receptor-expressing human trabecular meshwork progenitor cells.鉴定和应用表达 p75 神经营养因子受体的人眼小梁网祖细胞。
Biochem Biophys Res Commun. 2019 Jun 30;514(3):580-585. doi: 10.1016/j.bbrc.2019.04.178. Epub 2019 May 4.
8
Identification and characterization of mesenchymal stem cells derived from the trabecular meshwork of the human eye.人眼小梁组织来源的间充质干细胞的鉴定和特性研究。
Stem Cells Dev. 2012 Jun 10;21(9):1381-90. doi: 10.1089/scd.2011.0655. Epub 2012 Apr 16.
9
Characterizing differences between MSCs and TM cells: Toward autologous stem cell therapies for the glaucomatous trabecular meshwork.解析基质细胞和小梁细胞之间的差异：实现青光眼小梁网的自体干细胞治疗。
J Tissue Eng Regen Med. 2018 Mar;12(3):695-704. doi: 10.1002/term.2488. Epub 2017 Sep 17.
10
Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma.在青光眼转基因小鼠模型中，诱导多能干细胞来源的小梁网细胞移植后房水流出的恢复
Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2054-2062. doi: 10.1167/iovs.16-20672.
引用本文的文献
1
Tackling visual impairment: emerging avenues in ophthalmology.应对视力障碍：眼科学的新途径
Front Med (Lausanne). 2025 Apr 28;12:1567159. doi: 10.3389/fmed.2025.1567159. eCollection 2025.
2
Glaucoma: Current and New Therapeutic Approaches.青光眼：当前及新的治疗方法
Biomedicines. 2024 Sep 3;12(9):2000. doi: 10.3390/biomedicines12092000.
3
Development of Cell Culture Platforms for Study of Trabecular Meshwork Cells and Glaucoma Development.用于研究小梁细胞和青光眼发展的细胞培养平台的开发。
Tissue Eng Regen Med. 2024 Jul;21(5):695-710. doi: 10.1007/s13770-024-00640-6. Epub 2024 Apr 20.
4
Long non-coding RNA SNHG11 regulates the Wnt/β-catenin signaling pathway through rho/ROCK in trabecular meshwork cells.长链非编码RNA SNHG11通过小梁网细胞中的rho/ROCK调节Wnt/β-连环蛋白信号通路。
FASEB J. 2023 Apr;37(4):e22873. doi: 10.1096/fj.202201733RRR.
5
All- Retinoic Acids Synergistically and Beneficially Affect In Vitro Glaucomatous Trabecular Meshwork (TM) Models Using 2D and 3D Cell Cultures of Human TM Cells.全反式视黄酸协同并有益于使用人 TM 细胞的二维和三维细胞培养物的体外青光眼小梁网（TM）模型。
Int J Mol Sci. 2022 Aug 31;23(17):9912. doi: 10.3390/ijms23179912.
6
Newer advances in medical management of glaucoma.青光眼的医学管理新进展。
Indian J Ophthalmol. 2022 Jun;70(6):1920-1930. doi: 10.4103/ijo.IJO_2239_21.
7
Suppression of TGF-β1 signaling by Matrigel via FAK signaling in cultured human trabecular meshwork cells.基质胶通过黏着斑激酶信号通路抑制培养的人眼小梁细胞中的转化生长因子-β1 信号通路。
Sci Rep. 2021 Apr 1;11(1):7319. doi: 10.1038/s41598-021-86591-7.
8
Normal and glaucomatous outflow regulation.正常和青光眼性房水流出调节。
Prog Retin Eye Res. 2021 May;82:100897. doi: 10.1016/j.preteyeres.2020.100897. Epub 2020 Aug 11.
9
Human Trabecular Meshwork Progenitors.人眼小梁网祖细胞。
Int J Med Sci. 2019 May 10;16(5):704-710. doi: 10.7150/ijms.32089. eCollection 2019.
本文引用的文献
1
Isolation and Expansion of Multipotent Progenitors from Human Trabecular Meshwork.人眼小梁组织多能祖细胞的分离和扩增。
Sci Rep. 2018 Feb 12;8(1):2814. doi: 10.1038/s41598-018-21098-2.
2
CRISPR-Cas9-based treatment of myocilin-associated glaucoma.基于 CRISPR-Cas9 的肌球蛋白相关青光眼治疗。
Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11199-11204. doi: 10.1073/pnas.1706193114. Epub 2017 Oct 2.
3
Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma.在青光眼转基因小鼠模型中，诱导多能干细胞来源的小梁网细胞移植后房水流出的恢复
Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2054-2062. doi: 10.1167/iovs.16-20672.
4
Senescence Mediated by p16 Impedes Reprogramming of Human Corneal Endothelial Cells into Neural Crest Progenitors.由p16介导的衰老阻碍人角膜内皮细胞重编程为神经嵴祖细胞。
Sci Rep. 2016 Oct 14;6:35166. doi: 10.1038/srep35166.
5
Emerging Concepts in Glaucoma and Review of the Literature.青光眼的新观念及文献综述
Am J Med. 2016 Sep;129(9):1000.e7-1000.e13. doi: 10.1016/j.amjmed.2016.03.038. Epub 2016 Apr 26.
6
HC-HA/PTX3 Purified From Amniotic Membrane Promotes BMP Signaling in Limbal Niche Cells to Maintain Quiescence of Limbal Epithelial Progenitor/Stem Cells.从羊膜中纯化的HC-HA/PTX3促进角膜缘生态位细胞中的骨形态发生蛋白信号传导，以维持角膜缘上皮祖细胞/干细胞的静止状态。
Stem Cells. 2015 Nov;33(11):3341-55. doi: 10.1002/stem.2091. Epub 2015 Jul 16.
7
The Trabecular Meshwork: A Basic Review of Form and Function.小梁网：形态与功能的基础综述
J Ocul Biol. 2014 May;2(1). doi: 10.13188/2334-2838.1000017.
8
Identification of adult stem cells in Schwalbe's line region of the primate eye.灵长类动物眼睛施瓦贝线区域成体干细胞的鉴定。
Invest Ophthalmol Vis Sci. 2014 Oct 16;55(11):7499-507. doi: 10.1167/iovs.14-14872.
9
Activation of RhoA-ROCK-BMP signaling reprograms adult human corneal endothelial cells.RhoA-ROCK-BMP信号通路的激活可重编程成人人类角膜内皮细胞。
J Cell Biol. 2014 Sep 15;206(6):799-811. doi: 10.1083/jcb.201404032. Epub 2014 Sep 8.
10
Isolation and characterization of mesenchymal progenitor cells from human orbital adipose tissue.人眼眶脂肪组织中间充质祖细胞的分离与鉴定
Invest Ophthalmol Vis Sci. 2014 Jul 3;55(8):4842-52. doi: 10.1167/iovs.14-14441.
Zotero 插件