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本文引用的文献

1
Isolation and Expansion of Multipotent Progenitors from Human Trabecular Meshwork.人眼小梁组织多能祖细胞的分离和扩增。
Sci Rep. 2018 Feb 12;8(1):2814. doi: 10.1038/s41598-018-21098-2.
2
CRISPR-Cas9-based treatment of myocilin-associated glaucoma.基于 CRISPR-Cas9 的肌球蛋白相关青光眼治疗。
Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11199-11204. doi: 10.1073/pnas.1706193114. Epub 2017 Oct 2.
3
Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma.在青光眼转基因小鼠模型中，诱导多能干细胞来源的小梁网细胞移植后房水流出的恢复
Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2054-2062. doi: 10.1167/iovs.16-20672.
4
Senescence Mediated by p16 Impedes Reprogramming of Human Corneal Endothelial Cells into Neural Crest Progenitors.由p16介导的衰老阻碍人角膜内皮细胞重编程为神经嵴祖细胞。
Sci Rep. 2016 Oct 14;6:35166. doi: 10.1038/srep35166.
5
Emerging Concepts in Glaucoma and Review of the Literature.青光眼的新观念及文献综述
Am J Med. 2016 Sep;129(9):1000.e7-1000.e13. doi: 10.1016/j.amjmed.2016.03.038. Epub 2016 Apr 26.
6
HC-HA/PTX3 Purified From Amniotic Membrane Promotes BMP Signaling in Limbal Niche Cells to Maintain Quiescence of Limbal Epithelial Progenitor/Stem Cells.从羊膜中纯化的HC-HA/PTX3促进角膜缘生态位细胞中的骨形态发生蛋白信号传导，以维持角膜缘上皮祖细胞/干细胞的静止状态。
Stem Cells. 2015 Nov;33(11):3341-55. doi: 10.1002/stem.2091. Epub 2015 Jul 16.
7
The Trabecular Meshwork: A Basic Review of Form and Function.小梁网：形态与功能的基础综述
J Ocul Biol. 2014 May;2(1). doi: 10.13188/2334-2838.1000017.
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Identification of adult stem cells in Schwalbe's line region of the primate eye.灵长类动物眼睛施瓦贝线区域成体干细胞的鉴定。
Invest Ophthalmol Vis Sci. 2014 Oct 16;55(11):7499-507. doi: 10.1167/iovs.14-14872.
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Activation of RhoA-ROCK-BMP signaling reprograms adult human corneal endothelial cells.RhoA-ROCK-BMP信号通路的激活可重编程成人人类角膜内皮细胞。
J Cell Biol. 2014 Sep 15;206(6):799-811. doi: 10.1083/jcb.201404032. Epub 2014 Sep 8.
10
Isolation and characterization of mesenchymal progenitor cells from human orbital adipose tissue.人眼眶脂肪组织中间充质祖细胞的分离与鉴定
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小梁网细胞是青光眼细胞治疗的宝贵资源。

Trabecular meshwork cells are a valuable resource for cellular therapy of glaucoma.

机构信息

Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Department of Ophthalmology, the Second People's Hospital of Yunnan Province (Fourth Affiliated Hospital of Kunming Medical University), Yunnan Eye Institute, Key Laboratory of Yunnan Province for the Prevention and Treatment of Ophthalmology (2017DG008), Provincial Innovation Team for Cataract and Ocular Fundus Disease, The Second People's Hospital of Yunnan Province (2017HC010), Expert Workstation of Yao Ke (2017IC064), Kunming, China.

出版信息

J Cell Mol Med. 2019 Mar;23(3):1678-1686. doi: 10.1111/jcmm.14158. Epub 2019 Jan 18.

DOI:10.1111/jcmm.14158
PMID:30659738
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6378204/
Abstract

Trabecular meshwork (TM) contains a subset of adult stem cells or progenitors that can be differentiated into corneal endothelial cells, adipocytes and chondrocytes, but not osteocytes or keratocytes. Accordingly, these progenitors can be utilized as a cell-based therapy to prevent blindness caused by glaucoma, corneal endothelial dysfunction and other diseases in general. In this review, we review in vitro expansion techniques for TM progenitors, discuss their phenotypic properties, and highlight their potential clinical applications in various ophthalmic diseases.

摘要

小梁网（TM）包含一组成人干细胞或祖细胞，这些细胞可分化为角膜内皮细胞、脂肪细胞和成软骨细胞，但不能分化为成骨细胞或角膜细胞。因此，这些祖细胞可以用作基于细胞的治疗方法，以预防青光眼、角膜内皮功能障碍和其他一般疾病引起的失明。在这篇综述中，我们回顾了 TM 祖细胞的体外扩增技术，讨论了它们的表型特性，并强调了它们在各种眼科疾病中的潜在临床应用。