Internal Medicine Pulmonary, University of Nebraska Medical Center, Omaha, NE 68198, USA.
College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Nutrients. 2019 Feb 1;11(2):317. doi: 10.3390/nu11020317.
Nutritional status is a well-recognized prognostic indicator in chronic obstructive pulmonary disease (COPD); however, very little is known about the relationship between lung function and saturated fat intake. We used data from the cross-sectional National Health and Nutrition Examination Surveys (NHANES) to assess the relationship between saturated fatty acid (SFA) intake and lung function in the general US adult population. Adults in NHANES (2007⁻2012) with pre-bronchodilator spirometry measurements and dietary SFA intake were included. Primary outcomes were lung function including forced expiratory volume in one second (FEV₁) FEV₁, forced vital capacity (FVC), FEV₁/FVC ratio, percent predicted FEV₁ and percent predicted FVC. Multivariable regression models in the general population as well as those with spirometry-defined airflow obstruction were used to assess the relationship between lung function measurements and dietary SFA intake after adjustment for confounders. 11,180 eligible participants were included in this study. Univariate analysis revealed a statistically significant positive association between total SFA intake and lung function outcomes; however, these relationships were attenuated after adjustment for covariates. A secondary analysis of individuals with spirometry-defined airflow obstruction (FEV₁/FVC < 0.7) revealed that a lower intake of SFA was associated with reduced FEV (β = -126.4, = 0.04 for quartile 1 vs. quartile 4), FVC (β = -165.8. = 0.01 for quartile 1 vs. quartile 4), and percent predicted FVC (β = -3.3. = 0.04 for quartile 1 vs. quartile 4), after adjustment for relevant confounders. No associations were observed for the FEV₁/FVC ratio and percent predicted FEV₁. It is possible that characteristics such as food source and fatty acid chain length may influence associations between saturated fatty acid intake and health outcomes.
营养状况是慢性阻塞性肺疾病（COPD）的一个公认的预后指标；然而，对于肺功能与饱和脂肪摄入量之间的关系知之甚少。我们使用来自横断面全国健康和营养检查调查（NHANES）的数据，评估了普通美国成年人群体中饱和脂肪酸（SFA）摄入量与肺功能之间的关系。NHANES 中（2007-2012 年）有支气管扩张剂前肺量测定和饮食 SFA 摄入量的成年人被纳入研究。主要结局是肺功能，包括 1 秒用力呼气量（FEV₁）、FEV₁、用力肺活量（FVC）、FEV₁/FVC 比值、预测 FEV₁的百分比和预测 FVC 的百分比。在一般人群中以及在有支气管扩张剂定义的气流阻塞的人群中，使用多变量回归模型来评估肺功能测量值与饮食 SFA 摄入量之间的关系，这些关系在调整混杂因素后进行评估。本研究共纳入 11180 名符合条件的参与者。单变量分析显示，总 SFA 摄入量与肺功能结果之间存在统计学上显著的正相关；然而，这些关系在调整协变量后减弱了。对有支气管扩张剂定义的气流阻塞（FEV₁/FVC < 0.7）的个体进行的二次分析显示，较低的 SFA 摄入量与 FEV 降低相关（β = -126.4，四分位数 1 与四分位数 4 相比， = 0.04）、FVC（β = -165.8，四分位数 1 与四分位数 4 相比， = 0.01）和预测 FVC 的百分比（β = -3.3，四分位数 1 与四分位数 4 相比， = 0.04），在调整相关混杂因素后。FEV₁/FVC 比值和预测 FEV₁的百分比无相关性。可能是食物来源和脂肪酸链长等特征影响了饱和脂肪酸摄入量与健康结果之间的关系。
