Department of Pharmaceutical Sciences and Pharmaceutics, Faculty of Pharmacy, Applied Science Private University, Amman 11931, Jordan.
Nanoscale. 2019 Jan 31;11(5):2306-2316. doi: 10.1039/c8nr09067j.
Protein-corona formation in body fluids and/or entrapment of nanoparticles in protein matrices (e.g. food and mucus) can hinder the delivery of nanoparticles, irrespective of the route of administration. Here we demonstrate that certain viral nanoparticles (VNPs) can evade the adhesion of a broad panel of macromolecules from several biological milieus. We also show that the permeability of VNPs through mucin gels is far superior to that of synthetic nanoparticles. The non-sticky nature of VNPs implies that they will be able to readily cross most non-specific protein and glycoprotein barriers encountered, ubiquitously, upon administration through mucosal, and non-mucosal routes.
在体液中形成的蛋白质-冠和/或纳米颗粒被困在蛋白质基质中（例如食物和黏液），可能会阻碍纳米颗粒的递送，而不论给药途径如何。在这里，我们证明了某些病毒纳米颗粒（VNPs）可以逃避来自几种生物环境的多种大分子的粘附。我们还表明，VNPs 通过黏蛋白凝胶的渗透性远远优于合成纳米颗粒。VNPs 的非粘性性质意味着它们将能够轻易地穿过大多数非特异性蛋白质和糖蛋白屏障，这些屏障在通过黏膜和非黏膜途径给药时普遍存在。
