Institut Català de Nanociència i Nanotecnologia (ICN2), CSIC and The Barcelona Institute of Science and Technology (BIST), Campus UAB, 08193, Bellaterra, Barcelona, Spain; Universitat Autonoma de Barcelona, 08193, Bellaterra, Spain.
Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain; Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.
Semin Immunol. 2017 Dec;34:52-60. doi: 10.1016/j.smim.2017.10.001. Epub 2017 Oct 21.
The interaction of inorganic nanoparticles and many biological fluids often withstands the formation of a Protein Corona enveloping the nanoparticle. This Protein Corona provides the biological identity to the nanoparticle that the immune system will detect. The formation of this Protein Corona depends not only on the composition of the nanoparticle, its size, shape, surface state and exposure time, but also on the type of media, nanoparticle to protein ratio and the presence of ions and other molecular species that interfere in the interaction between proteins and nanoparticles. This has important implications on immune safety, biocompatibility and the use of nanoparticles in medicine.
无机纳米粒子与许多生物流体的相互作用往往会形成一层包裹纳米粒子的蛋白质外壳，即所谓的“蛋白冠”。这层蛋白冠赋予了纳米粒子生物学特性，使其成为免疫系统识别的目标。蛋白冠的形成不仅取决于纳米粒子的组成、大小、形状、表面状态和暴露时间，还取决于介质类型、纳米粒子与蛋白质的比例以及存在的离子和其他干扰蛋白质与纳米粒子相互作用的分子种类。这对免疫安全性、生物相容性以及纳米粒子在医学中的应用都有重要影响。
