Research Centre for Medical Genetics, 1 Moskvorechie str, Moscow, 115478, Russia.
Stowers Institute for Medical Research, 1000 E. 50th St, Kansas City, MO, 64110, USA.
Chromosome Res. 2019 Mar;27(1-2):1-3. doi: 10.1007/s10577-018-9601-4. Epub 2019 Jan 21.
Ribosomal DNA, the topic of this special issue, has long fascinated biologists. The RNA products of the ribosomal DNA are the ribosomal RNAs that are part of the ribosome. In this special issue, we focus on the sequence, molecular organization, repair, stability, copy number, and peculiar genetics of this region of the genome. The locus can impact not only the translational capability of cells, but also genome organization, stability and integrity, providing a link between translation and chromosome biology.
核糖体 DNA 一直是生物学家长期关注的焦点。核糖体 DNA 的 RNA 产物是核糖体的一部分核糖体 RNA。在本期特刊中，我们重点关注基因组这一区域的序列、分子组织、修复、稳定性、拷贝数和特殊遗传学。该基因座不仅可以影响细胞的翻译能力，还可以影响基因组的组织、稳定性和完整性，在翻译和染色体生物学之间建立联系。
