尼古丁所致内皮损伤及其预防
Endothelial injury by nicotine and its prevention.
作者信息
Hladovec J
出版信息
Experientia. 1978 Dec 15;34(12):1585-6. doi: 10.1007/BF02034689.
PMID:729720
Abstract
Nicotine administered i.v. or p.o. in doses above 0.0125 mg/kg to the rat caused a highly significant increase in circulating anuclear carcasses of endothelial cells estimated by an original method. This effect of nicotine was completely prevented by a prior oral administration of the flavonoids hydroxyethylrutosides (HR) or Mono-7-HR.
摘要
以高于0.0125毫克/千克的剂量给大鼠静脉注射或口服尼古丁，通过一种原始方法估计，会导致循环中的内皮细胞无核尸体显著增加。尼古丁的这种作用可通过事先口服黄酮类化合物羟乙基芦丁（HR）或单-7-HR完全预防。
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