急性沉默海马 CA3 揭示了其在位置场反应中的主导作用。
Acute silencing of hippocampal CA3 reveals a dominant role in place field responses.
机构信息
Department of Psychology, University of California, Berkeley, Berkeley, CA, USA.
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
出版信息
Nat Neurosci. 2019 Mar;22(3):337-342. doi: 10.1038/s41593-018-0321-z. Epub 2019 Jan 21.
Neurons in hippocampal output area CA1 are thought to exhibit redundancy across cortical and hippocampal inputs. Here we show instead that acute silencing of CA3 terminals drastically reduces place field responses for many CA1 neurons, while a smaller number are unaffected or have increased responses. These results imply that CA3 is the predominant driver of CA1 place cells under normal conditions, while also revealing heterogeneity in input dominance across cells.
海马体输出区域 CA1 中的神经元被认为在皮质和海马体输入中表现出冗余。然而，我们发现，急性抑制 CA3 末梢会大大降低许多 CA1 神经元的位置场反应，而少数神经元不受影响或反应增强。这些结果表明，CA3 是正常情况下 CA1 位置细胞的主要驱动者，同时也揭示了细胞间输入主导性的异质性。
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