Alonso María Rosario, Damonte Silvia Pérez, Anesini Claudia
Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química y Metabolismo del Fármaco (IQUIMEFA), Department of Pharmacology, Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina,
CLAIM, José Bonifacio 717 (C1424 CHO) Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
Clin Cosmet Investig Dermatol. 2019 Jan 9;12:47-55. doi: 10.2147/CCID.S182497. eCollection 2019.
A combination of extracts, from two plant species, ie, and (Jarilla) (ECOHAIR) is being successfully used in Argentina as a cosmetic for hair recovery in androgenic and areata alopecia, and for eyelash and eyebrow growth. The objectives of this prospective study were to evaluate the capacity of Jarilla-Coffea extract gel of improving hair growth in relation to thickness, appearance of new hair, and hair length in comparison with a placebo in premenopausal and postmenopausal volunteers and to identify possible signs of ocular adverse local reactions related to the application of the gel.
An open-label, placebo-controlled, prospective study was performed in healthy premenopausal and postmenopausal women during a daily administration period of 2 months (eyebrow growth) and 3 months (eyelash growth). The thickness of hair was determined using a video microscope MedicalScope. The appearance of new hairs and total area with hair in eyebrow and eyelash length were quantified using a photographic record with Fotofinder (Germany). The number of volunteers presenting variation in growth of new hair and length were also recorded.
The product significantly increased the thickness of eyebrows (20% in 80% women) and eyelashes (19.44% in 100% of women). The gel also increased the appearance of new hairs, total area with hair, and length but there was no statistical difference between treatment and placebo.
The gel was capable of improving growth of eyelashes and eyebrows by inducing principally hair thickening without causing local adverse effects in a high percentage of volunteers.
来自两种植物（即[未提及的植物名称1]和[未提及的植物名称2]（Jarilla）（ECOHAIR））的提取物组合在阿根廷被成功用作一种化妆品，用于雄激素性脱发和斑秃的头发恢复，以及睫毛和眉毛的生长。这项前瞻性研究的目的是评估与安慰剂相比，Jarilla - 咖啡提取物凝胶在改善绝经前和绝经后志愿者头发厚度、新发生长外观以及头发长度方面促进头发生长的能力，并确定与凝胶应用相关的眼部局部不良反应的可能迹象。
在健康的绝经前和绝经后女性中进行了一项开放标签、安慰剂对照的前瞻性研究，每日给药期为2个月（眉毛生长）和3个月（睫毛生长）。使用视频显微镜MedicalScope测定头发厚度。使用德国的Fotofinder进行摄影记录，对眉毛和睫毛中新发的外观以及有头发的总面积和长度进行量化。还记录了新发生长和长度有变化的志愿者人数。
该产品显著增加了眉毛厚度（80%的女性增加了20%）和睫毛厚度（100%的女性增加了19.44%）。凝胶还增加了新头发的外观、有头发的总面积和长度，但治疗组与安慰剂组之间无统计学差异。
该凝胶能够通过主要诱导头发变厚来改善睫毛和眉毛的生长，且在高比例的志愿者中未引起局部不良反应。
